Left hemispheric dominance of vestibular processing indicates lateralization of cortical functions in rats
Left hemispheric dominance of vestibular processing indicates lateralization of cortical functions in rats
复制标题
DOI：
10.1007/s00429-013-0628-1
复制
发表时间：
2014-11-01
影响因子：
3.1
通讯作者：
Dieterich, Marianne
中科院分区：
文献类型：
--
作者：
Best, Christoph;Lange, Elena;Dieterich, Marianne
大脑皮层功能的偏侧化，如语言优势、利手和前庭信息的处理，不仅存在于人类，而且存在于个体发育的老年物种，如大鼠。在人类功能成像研究中，前庭信息的处理被发现与由利手决定的半球优势相关。它主要位于右利手的右半球和左利手的左半球。由于前庭处理的优势是未知的动物，我们的目的是研究大脑皮层处理的偏侧化的功能成像研究应用小动物正电子发射断层扫描（microPET）和前庭电刺激在体内大鼠模型。皮质和皮质下的网络处理前庭信息可以证明和相关的数据从其他动物的研究。通过计算偏侧化指数以及翻转感兴趣区域的分析，我们发现大鼠的前庭处理遵循一个强大的左半球的优势，独立于动物的"利手"。这些研究结果支持的想法，早期半球专业化的前庭皮质功能的个体发育的老年人。
Lateralization of cortical functions such as speech dominance, handedness and processing of vestibular information are present not only in humans but also in ontogenetic older species, e.g. rats. In human functional imaging studies, the processing of vestibular information was found to be correlated with the hemispherical dominance as determined by the handedness. It is located mainly within the right hemisphere in right handers and within the left hemisphere in left handers. Since dominance of vestibular processing is unknown in animals, our aim was to study the lateralization of cortical processing in a functional imaging study applying small-animal positron emission tomography (microPET) and galvanic vestibular stimulation in an in vivo rat model. The cortical and subcortical network processing vestibular information could be demonstrated and correlated with data from other animal studies. By calculating a lateralization index as well as flipped region of interest analyses, we found that the vestibular processing in rats follows a strong left hemispheric dominance independent from the "handedness" of the animals. These findings support the idea of an early hemispheric specialization of vestibular cortical functions in ontogenetic older species.