LANGERHANS CELLS AND LYMPHOCYTE SUBSETS IN THE FEMALE GENITAL-TRACT
LANGERHANS CELLS AND LYMPHOCYTE SUBSETS IN THE FEMALE GENITAL-TRACT
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DOI：
10.1111/j.1471-0528.1985.tb03080.x
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
MORRIS, HB
中科院分区：
文献类型：
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作者：
EDWARDS, JNT;MORRIS, HB
使用免疫组织学标记技术和一组识别朗格汉斯细胞、T淋巴细胞和B淋巴细胞以及HLA-DR抗原的单克隆抗体对健康宫颈、阴道和外阴上皮的冷冻切片进行检查。宫颈、阴道和外阴鳞状上皮中郎格罕细胞的分布有明显差异，外阴中位值最高（18.7/100个基底鳞状细胞），阴道中位值最低（5.5/100个基底鳞状细胞）。这三个区域的淋巴细胞的数量和分布也有很大的变化，在宫颈的转化区有明显的优势。此外，上皮内淋巴细胞，主要是T-细胞毒性抑制子亚型存在于所有网站的转化区中的最大数量。我们从这项研究中得出结论，宫颈转化区的淋巴组织有几个独特的特点，没有观察到在下生殖道的其他网站。我们建议将该组织命名为“颈部淋巴组织”，并且它形成了“粘膜相关淋巴组织”（MALT）的一部分，如在暴露于外部环境的其他粘膜部位所述。
Cryostat sections of healthy cervical, vaginal and vulval epithelium were examined using immunohistological labelling techniques and a panel of monoclonal antibodies recognizing Langerhans'' cells, T- and B-lymphocytes and HLA-DR antigen. The distribution of Langerhans'' cells in squamous epithelium of the cervix, vagina and vulva showed a marked variation with the highest median values in the vulva (18.7 per 100 basal squamous cells) and the lowest in the vagina (5.5 per 100 basal squamous cells). There was also a substantial variation in number and distribution of lymphocytes of each of these three areas with a distinct preponderance in the transformation zone of the cervix. In addition, intraepithelial lymphocytes, predominantly of the T-cytotoxic suppressor sub-type were present at all sites with the greatest number in the transformation zone. We conclude from this study that lymphoid tissue of the cervical transformation zone has several unique characteristics which are not observed at other sites in the lower genital tract. We suggest that this tissue be designated '' cervical lymphoid tissue'' and that it forms a part of the ''mucosal associated lymphoid tissue'' (MALT) as noted at other mucosal sites exposed to the external environment.