Titanium implants in irradiated dog mandibles.
Titanium implants in irradiated dog mandibles.
复制标题
受辐射的狗下颌骨中的钛植入物。
DOI：
10.1016/0022-3913(89)90314-4
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
J. Schweiger
中科院分区：
文献类型：
--
作者：
J. Schweiger
骨整合钛种植体的使用对选定的癌症患者有很大的益处，否则他们将无法佩戴传统和/或颌面假体。认识到放射性骨坏死的风险，我们使用动物模型来寻找放射到肿瘤杀伤水平的骨中成功骨整合的实验证据。5只健康雄性比格犬在右侧半下颌骨的先前无齿和愈合区域接受60 gray。左半下颌骨作为未照射对照。9个月后，放置钛种植体，并允许额外的5个半月的骨整合。当时，获得块标本，进行X线摄影、拍照和组织学分析。虽然结果不具有统计学意义，但在一半的辐照样本中实现了骨整合。
The use of osseointegrated titanium implants has been a great benefit to selected cancer patients who otherwise would not be able to wear conventional and/or maxillofacial prostheses. Cognizant, of the risk of osteoradionecrosis, we used an animal model to seek experimental evidence for successful osseointegration in bone irradiated to tumoricidal levels. Five healthy male beagle dogs received 60 gray to a previously edentulated and healed area of the right hemimandible. The left hemimandible was kept as a nonirradiated control. After 9 months, titanium implants were placed and allowed an additional 5 1/2 months to osseointegrate. At that time, block specimens were obtained, radiographed, photographed, and analyzed histologically. Although statistical significance cannot be attached to the results, osseointegration was achieved in half of the irradiated specimens.