Sympathetic neural activation in nondiabetic metabolic syndrome and its further augmentation by hypertension
Sympathetic neural activation in nondiabetic metabolic syndrome and its further augmentation by hypertension
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DOI：
10.1161/01.hyp.0000147893.08533.d8
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发表时间：
2004-12-01
期刊：
影响因子：
8.3
通讯作者：
Mary, DASG
中科院分区：
文献类型：
--
作者：
Huggett, RJ;Burns, J;Mary, DASG
高血压是代谢综合征（MS）中的主要心血管危险因素，其中胰岛素抵抗、葡萄糖耐受不良、脂蛋白代谢异常和中心性肥胖的存在都增加了风险。由于原发性高血压（EHT）、胰岛素血症和内脏脂肪与交感神经功能亢进相关，而交感神经功能亢进本身已知会增加心血管风险，因此本研究的目的是观察MS是否是交感神经功能亢进的一种状态，以及EHT的额外存在是否会加剧这种亢进。在69名密切匹配的受试者中，包括高血压MS（MS+EHT，18），正常血压MS（MS-EHT，17），无MS的高血压患者（EHT，16）和无MS的正常血压对照（NC，18），我们测量了静息肌肉交感神经活动（MSNA），从多单位放电和具有明确血管收缩特性的单一单位（s-MSNA）评估。MS+EHT组的s-MSNA（76+/-3.1脉冲/100次搏动）更高（至少P
Hypertension is a major cardiovascular risk factor in the metabolic syndrome ( MS) in which the presence of insulin resistance, glucose intolerance, abnormal lipoprotein metabolism, and central obesity all confer an increased risk. Because essential hypertension (EHT), insulinemia, and visceral fat are associated with sympathetic hyperactivity, which is itself known to increase cardiovascular risk, the aim of this study was to see if MS is a state of sympathetic nerve hyperactivity and if the additional presence of EHT intensifies this hyperactivity. In 69 closely matched subjects, comprising hypertensive MS (MS+EHT, 18), normotensive MS (MS-EHT, 17), hypertensives without MS (EHT, 16), and normotensive controls without MS (NC, 18), we measured resting muscle sympathetic nerve activity (MSNA) as assessed from multiunit discharges and from single units with defined vasoconstrictor properties (s-MSNA). The s-MSNA in MS+EHT (76+/-3.1 impulses/100 beats) was greater (at least P