Parkinsonian Beta Dynamics during Rest and Movement in the Dorsal Pallidum and Subthalamic Nucleus
Parkinsonian Beta Dynamics during Rest and Movement in the Dorsal Pallidum and Subthalamic Nucleus
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DOI：
10.1523/jneurosci.2113-19.2020
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发表时间：
2020-04-01
影响因子：
5.3
通讯作者：
Gunduz, Aysegul
中科院分区：
文献类型：
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作者：
Eisinger, Robert S.;Cagle, Jackson N.;Gunduz, Aysegul
在帕金森病（PD）中，病理高水平的β活性（12-30 Hz）反映了特定的症状，并通过药物或手术干预使其正常化。虽然在接受深部脑刺激（DBS）的PD患者的丘脑下核（STN）中的β表征现在已经被转化为适应性DBS范式，但有限数量的研究已经表征了白白球（GPi）中的β功率，这是一个同样有效的DBS靶点。我们的目的是比较PD患者在接受DBS的休息和运动期间STN和GPi的β功率。37名男性和女性参与者完成了一项简单的行为实验，包括休息和按按钮，从19个（15人）STN和26个（22人）GPi核中记录局部场电位。我们检查了总体的beta功率以及beta时域动态（即beta脉冲）。我们发现GPi在休息和运动时β功率更高，运动时β不同步也更多。-功率与运动迟缓和僵硬严重程度呈正相关；然而，这些临床关联仅存在于GPi队列中。在β动力学方面，GPi和STN的爆发在持续时间和频率上相似，但GPi的爆发更强，并与运动迟缓-僵硬严重程度相关。因此，β动态在基底神经节核之间不同。相对于STN， GPi中的β能量可能很容易被检测到，随着运动而调节更多，并且与临床损伤更相关。总之，这可能表明GPi是基于β的适应性脑起搏器的潜在有效靶点。
In Parkinson's disease (PD), pathologically high levels of beta activity (12-30 Hz) reflect specific symptomatology and normalize with pharmacological or surgical intervention. Although beta characterization in the subthalamic nucleus (STN) of PD patients undergoing deep brain stimulation (DBS) has now been translated into adaptive DBS paradigms, a limited number of studies have characterized beta power in the globus pallidus intemus (GPi), an equally effective DBS target. Our objective was to compare beta power in the STN and GPi during rest and movement in people with PD undergoing DBS. Thirty-seven human female and male participants completed a simple behavioral experiment consisting of periods of rest and button presses, leading to local field potential recordings from 19 (15 participants) STN and 26 (22 participants) GPi nuclei. We examined overall beta power as well as beta time-domain dynamics (i.e., beta bursts). We found higher beta power during rest and movement in the GPi, which also had more beta desynchronization during movement. Beta power was positively associated with bradykinesia and rigidity severity; however, these clinical associations were present only in the GPi cohort. With regards to beta dynamics, bursts were similar in duration and frequency in the GPi and STN, but GPi bursts were stronger and correlated to bradykinesia-rigidity severity. Beta dynamics therefore differ across basal ganglia nuclei. Relative to the STN, beta power in the GPi may be readily detected, modulates more with movement, and relates more to clinical impairment. Together, this could point to the GPi as a potentially effective target for beta-based adaptive DBS.