Brain temperature changes coupled to sleep states persist during interleukin 1-enhanced sleep.
Brain temperature changes coupled to sleep states persist during interleukin 1-enhanced sleep.
复制标题
在白细胞介素 1 增强睡眠期间，与睡眠状态相关的大脑温度变化持续存在。
DOI：
10.1152/ajpregu.1986.250.1.r96
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Krueger,JM
中科院分区：
文献类型：
--
作者：
Walter,J;Davenne,D;Shoham,S;Dinarello,CA;Krueger,JM
观察了人白细胞介素1（IL 1）对家兔睡眠-觉醒周期结构和警觉状态下脑温（Tbr）变化的影响。脑室内输注IL 1可引起慢波睡眠（SWS）增加、脑电图慢波（0.5-4 Hz）振幅增加和发热。热灭活的IL 1不能引起这些反应。IL-1还显著抑制快速眼动（REM）睡眠;然而，失活的IL-1也减少REM睡眠;因此，IL-1诱导的REM减少可能与输注过程有关。睡眠周期的持续时间和数量（REM到REM间隔）不受IL 1的影响。同样，Tbr的变化，通常发生在从一个觉醒状态到另一个保持不变后IL 1输液，即使兔子同时发热。我们的结论是，IL-1选择性地增强SWS，而离开睡眠周期和TBR的变化耦合到不受干扰的警惕状态。
The effects of human interleukin 1 (IL 1) on the architecture of rabbit sleep-wake cycles and brain temperature (Tbr) changes coupled to states of vigilance were examined. Cerebral intraventricular infusion of IL 1 induced increased slow-wave sleep (SWS), increased electroencephalographic slow-wave (0.5-4 Hz) amplitudes, and fever. Heat-inactivated IL 1 failed to elicit these responses. IL 1 also significantly inhibited rapid-eye-movement (REM) sleep; however, inactivated IL 1 also reduced REM sleep; thus some of the IL 1-induced REM reduction may be related to the infusion process. The duration and number of sleep cycles (REM-to-REM interval) were unaffected by IL 1. Similarly, Tbr changes that normally occur during the transition from one arousal state to another remained unchanged after IL 1 infusion, even though rabbits were simultaneously febrile. We conclude that IL 1 selectively enhances SWS while leaving sleep cycles and Tbr changes coupled to states of vigilance undisturbed.