A MOTOR AREA ROSTRAL TO THE SUPPLEMENTARY MOTOR AREA (PRESUPPLEMENTARY MOTOR AREA) IN THE MONKEY - NEURONAL-ACTIVITY DURING A LEARNED MOTOR TASK
A MOTOR AREA ROSTRAL TO THE SUPPLEMENTARY MOTOR AREA (PRESUPPLEMENTARY MOTOR AREA) IN THE MONKEY - NEURONAL-ACTIVITY DURING A LEARNED MOTOR TASK
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DOI：
10.1152/jn.1992.68.3.653
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发表时间：
1992-09-01
影响因子：
2.5
通讯作者：
TANJI, J
中科院分区：
文献类型：
--
作者：
MATSUZAKA, Y;AIZAWA, H;TANJI, J
1.本研究以猕猴（Macaca fuscata）的额皮质为研究对象，采用多种生理学方法，从吻尾侧划分出两个不同的区域，即额皮质吻内侧无颗粒区（SMA）.场和单一的反应，电刺激的初级运动皮层是不同的尾侧部分，但最小或不存在的吻侧部分。皮质内微刺激很容易诱发肢体或orofacial运动的尾部，但很少在喙部。神经元对视觉刺激的反应主要发生在喙部，但躯体感觉反应很少。尾侧部则相反。吻侧部分，大致对应于6 abeta区，被操作定义为前补充运动区（前SMA）。尾侧部分被重新定义为SMA本身。SMA前区的单细胞活性与SMA固有区的单细胞活性进行定量比较，以确定与训练运动任务相关的单细胞活性。在SMA前，视觉提示信号指示即将到来的手臂到达运动方向的相位反应更为丰富。在SMA前，运动准备期的活动变化更频繁，这一时期一直持续到到达运动的触发信号的发生。相性运动相关活动在SMA中更常见，并且其发作通常与运动发作时间锁定。在前SMA中，锁定到运动触发信号的反应时间的发生比SMA中更频繁。在这两个领域的神经元中，方向选择性被发现在所有的线索，准备和运动相关的反应。
1. The rostromesial agranular frontal cortex of macaque monkey (Macaca fuscata), traditionally defined as the supplementary motor area (SMA), was studied using various physiological techniques to delineate two different areas rostrocaudally.2. Field and unitary responses to electrical stimulation of the primary motor cortex were distinct in the caudal part, but minimal or absent in the rostral part. Intracortical microstimulation readily evoked limb or orofacial movements in the caudal part, but only infrequently in the rostral part. Neuronal responses to visual stimuli prevailed in the rostral part, but somatosensory responses were rare. The opposite was true in the caudal part.3. The rostral part, roughly corresponding to area 6abeta, was operationally defined as the presupplementary motor area (pre-SMA). The caudal part was redefined as the SMA proper.4. Single-cell activity in the pre-SMA was quantitatively compared with that in the SMA proper in relation to a trained motor task.5. Phasic responses to visual cue signals indicating the direction of forthcoming arm-reaching movement were more abundant in the pre-SMA.6. Activity changes during the preparatory period, which lasted until the occurrence of the trigger signal for the reaching movement, were more frequent in the pre-SMA.7. Phasic, movement-related activity was more frequent in the SMA, and its onset was often time locked to the movement onset. In the pre-SMA, the occurrences of response time locked to the movement-trigger signal were more frequent than in the SMA.8. Among neurons in both areas, directional selectivity was found in all the cue, preparatory, and movement-related responses.