Ultrasonographic diagnosis and medical treatment of human cystic echinococcosis in asymptomatic school age carriers: 5 years of follow-up
Ultrasonographic diagnosis and medical treatment of human cystic echinococcosis in asymptomatic school age carriers: 5 years of follow-up
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DOI：
10.1016/j.actatropica.2004.02.006
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发表时间：
2004-06-01
期刊：
影响因子：
2.7
通讯作者：
Odriozola, M
中科院分区：
文献类型：
--
作者：
Larrieu, E;Del Carpio, M;Odriozola, M
由细粒棘球蚴引起的包虫病或囊性包虫病 (CE) 在阿根廷里奥内格罗省流行。本次调查的目的是评估 1997 年至 2002 年在阿根廷里奥内格罗省流行地区实施的一项计划的结果。使用腹部超声检查，根据世界卫生组织指南对发现的病例进行分类。根据囊肿类型和大小，确定了治疗方案，包括观察、阿苯达唑治疗、PAIR 或手术。总共对 5745 名学童进行了评估，其中 70 名（1.2%）检测出包虫囊肿携带者。其中； 40 例 (57.1%) 纳入随访方案，25 例 (35.7%) 接受阿苯达唑治疗方案，2 例 (2.9%) 接受 PAIR，3 例 (4.3%) 接受传统手术。平均 44 个月后，在接受阿苯达唑治疗的 25 例中，2 例 (8%) 囊肿完全消退，17 例 (68%) 出现积极变化，1 例出现积极变化。 (4%) 保持不变，4 种 (16%) 进展为 11 型，而 1 种 (4%) 则表现出负面的进化变化。在仅观察方案的 39 例病例中，8 例 (21%) 囊肿完全复旧，7 例 (18%) 出现积极变化，11 例 (28%) 保持不变，2 例 (5%) 进展为 II 型，II 例 (28%) 出现消极进化变化，必须纳入其他方案类型。在这项研究中，10%的检测病例采用了常规手术。超声筛查和阿苯达唑治疗相结合显示出有希望的结果。 (C) 2004 Elsevier B.V. 保留所有权利。
Hydatidosis or cystic echinococcosis (CE) caused by Echinococcus granulosus is endemic in the Province of Rio Negro, Argentina. The objective of this investigation was to evaluate the results of a program carried out in endemic areas of the Province of Rio Negro, Argentina, in the years 1997-2002. Abdominal ultrasonography was used, classifying the cases detected according to WHO guidelines. A treatment algorithm was defined which included observation, albendazol therapy, PAIR or surgery, according to cyst type and size.A total of 5745 schoolchildren were evaluated, detecting hydatid cyst carriers in 70 (1.2%). Of these; 40 (57.1%) were included in follow-up protocol, 25 (35.7%) in treatment protocol with albendazol, 2 (2.9%) with PAIR and 3 (4.3%) with conventional surgery.After a mean of 44 months, among 25 cases treated with albendazol, in 2 (8%) cysts underwent total involution, in 17 (68%) they presented positive changes, in one (4%) they remained unchanged and in 4 (16%) they progressed to type 11, while 1 (4%) displayed negative evolutionary changes. Out of 39 cases under observation alone protocol, in 8 cases (21%) cysts underwent total involution, in 7 (18%) they presented positive changes, in 11 (28%) they remained unchanged, in 2 (5%) they progressed to Type II and in II (28%) they presented negative evolutionary changes and had to be included in the other protocol types. In this study, conventional surgery, was applied to 10% of detected cases.The combination of ultrasonographic screening and albendazol treatment showed promising results. (C) 2004 Elsevier B.V. All rights reserved.