Consequences of extinction training on associative and non-associative fear in a mouse model of Posttraumatic Stress Disorder (PTSD)
Consequences of extinction training on associative and non-associative fear in a mouse model of Posttraumatic Stress Disorder (PTSD)
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DOI：
10.1016/j.bbr.2009.08.019
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发表时间：
2009-12-28
影响因子：
2.7
通讯作者：
Wotjak, Carsten T.
中科院分区：
文献类型：
--
作者：
Golub, Yulia;Mauch, Christoph P.;Wotjak, Carsten T.
创伤后应激障碍（PTSD）的临床治疗的一种常见方法集中在通过认知行为疗法促进恐惧消退，该疗法涉及安全暴露于创伤相关线索和随后的条件刺激-非条件刺激（CS-US）偶然性预期的变化。创伤后应激障碍的症状可以追溯到病理改变的联想恐惧。过度兴奋和时间依赖性恐惧综合症我们使用了一种基于短暂暴露于不可避免的足部电击的PTSD小鼠模型，以研究早期（从电击后第1天开始）和晚期（从电击后1个月开始）消退训练的影响。早期和晚期的灭绝训练导致了持久的减少上下文和广义的恐惧，但只有早期灭绝引起了改善过度觉醒因此，我们的研究结果表明，早期休克后干预作为一个成功的策略，减少过度觉醒的创伤后。(C)2009 Elsevier B. V.版权所有
A common approach to the clinical treatment of Posttraumatic Stress Disorder (PTSD) has focused on the facilitation of fear extinction through cognitive behavioural therapy that involves both safe exposure to the trauma-related cues and subsequent changes in conditioned stimulus-unconditioned stimulus (CS-US) contingency expectations. PTSD symptoms can be tracked back to pathologically modified associative fear. hyperarousal and a time-dependent fear generalization. We have used a mouse model of PTSD that is based on a brief exposure to an inescapable foot shock in order to investigate the influence of early (starting I day after the shock) and late (starting 1 month after the shock) extinction training. Both early and late extinction training led to a long-lasting reduction of contextual and generalized fear, but only early extinction caused an amelioration of hyperarousal Consequently, our results suggest early post-shock intervention as a successful strategy for reducing hyperarousal in the aftermath of a trauma. (C) 2009 Elsevier B.V. All rights reserved