Accrual to Clinical Trials (ACT): A Clinical and Translational Science Award Consortium Network.
Accrual to Clinical Trials (ACT): A Clinical and Translational Science Award Consortium Network.
复制标题
DOI：
10.1093/jamiaopen/ooy033
复制
发表时间：
2018-10
期刊：
影响因子：
2.1
通讯作者：
Reis SE
中科院分区：
文献类型：
--
作者：
Visweswaran S;Becich MJ;D'Itri VS;Sendro ER;MacFadden D;Anderson NR;Allen KA;Ranganathan D;Murphy SN;Morrato EH;Pincus HA;Toto R;Firestein GS;Nadler LM;Reis SE
应计到临床试验(ACT)网络是由国家临床和转化科学奖(CTSA)联盟的站点组成的联合网络，该联盟的创建是为了显著增加参与者对多站点临床试验的收益。ACT网络代表了CTSA不同站点之间前所未有的合作。该网络创建了治理和监管框架以及一个通用数据模型，以协调电子健康记录(EHR)数据，并部署了一套信息学，用于整合通过共享的卫生研究信息网络(Shine)平台链接的生物学和床边(I2b2)数据存储库。它为研究人员提供了实时查询网络的能力，并从美国各地的网站获得符合临床试验纳入和排除标准的患者的汇总计数。ACT网络基础设施为队列发现和开发新的信息学工具提供了基础，以确定和招募多地点临床试验的参与者。
The Accrual to Clinical Trials (ACT) network is a federated network of sites from the National Clinical and Translational Science Award (CTSA) Consortium that has been created to significantly increase participant accrual to multi-site clinical trials. The ACT network represents an unprecedented collaboration among diverse CTSA sites. The network has created governance and regulatory frameworks and a common data model to harmonize electronic health record (EHR) data, and deployed a set of Informatics for Integrating Biology and the Bedside (i2b2) data repositories that are linked by the Shared Health Research Information Network (SHRINE) platform. It provides investigators the ability to query the network in real time and to obtain aggregate counts of patients who meet clinical trial inclusion and exclusion criteria from sites across the United States. The ACT network infrastructure provides a basis for cohort discovery and for developing new informatics tools to identify and recruit participants for multi-site clinical trials.