Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures
Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures
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DOI：
10.1039/c7sm02188g
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发表时间：
2018-04-28
期刊：
影响因子：
3.4
通讯作者：
Imai, Masayuki
中科院分区：
文献类型：
--
作者：
Urakami, Naohito;Jimbo, Takehiro;Imai, Masayuki
我们使用粗粒度分子动力学模拟研究了脂质几何形状对囊泡分裂的影响。当囊泡由零自发曲率和负自发曲率脂质（ZSL 和 NSL）组成时，它们分子自发曲率的差异会破坏极限形状囊泡颈部的稳定性。在囊泡分裂途径中，颈部发育成茎中间体。当 NSL 从茎中排出时，茎被折断。自由能分析表明，脂质几何形状和高斯刚性之间的耦合是观察到的囊泡分裂的原因。
We investigated the effects of lipid geometry on vesicle division using coarse grained molecular dynamics simulations. When the vesicle is composed of zero and negative spontaneous curvature lipids (ZSLs and NSLs), the difference in their molecular spontaneous curvatures destabilizes the neck of the limiting shape vesicle. In the vesicle division pathway, the neck developed into the stalk intermediates. The stalk was broken when the NSLs were expelled from the stalk. Free energy analysis shows that the coupling between the lipid geometry and the Gaussian rigidity is responsible for the observed vesicle division.