Cu-Catalyzed Arylation/Acyl Migration Cascade Reaction of Enaminones: Access to N-Fused Polycyclic and 2,3-Disubstituted Indoles
Cu-Catalyzed Arylation/Acyl Migration Cascade Reaction of Enaminones: Access to N-Fused Polycyclic and 2,3-Disubstituted Indoles
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铜催化烯胺酮的芳基化/酰基迁移级联反应：获得 N-稠合多环和 2,3-二取代吲哚
DOI：
10.1021/acs.joc.9b00866
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发表时间：
2019-06-21
影响因子：
3.6
通讯作者：
Liu, Wen-Bo
中科院分区：
文献类型：
--
作者：
Li, Weishuang;Dong, Zhan;Liu, Wen-Bo
报道了用铜催化的胺酮直接环化/酰基迁移反应高效合成n -熔融多环和2,3-二取代吲哚。该策略具有催化剂/配体的廉价和低负荷，易于获得的起始材料，以及良好的官能团相容性。值得注意的是，含烯丙基的底物也是耐受的，这允许下游衍生为吲哚生物碱。
An efficient synthesis of N-fused polycyclic and 2,3-disubstituted indoles by copper-catalyzed direct annulation/acyl migration reaction of enaminones is reported. This strategy features cheap and low loading of the catalyst/ligand, readily available starting materials, and good functional group compatibilities. Notably, allyl-containing substrates are also tolerated, which allows the downstream derivatization toward indole alkaloids.