PROTECTIVE EFFECTS OF MELATONIN IN MICE INFECTED WITH ENCEPHALITIS VIRUSES
PROTECTIVE EFFECTS OF MELATONIN IN MICE INFECTED WITH ENCEPHALITIS VIRUSES
复制标题
DOI：
10.1007/bf01309858
复制
发表时间：
1995-01-01
影响因子：
2.7
通讯作者：
CONTI, A
中科院分区：
文献类型：
--
作者：
BENNATHAN, D;MAESTRONI, GJM;CONTI, A
我们检查了松果体神经激素褪黑激素（MLT）对预防病毒性脑炎的作用。在接种塞姆利基森林病毒 (SFV) 的正常小鼠和注射减毒非侵入性西尼罗河病毒 (WN-25) 的应激小鼠中评估了 MLT 的抗病毒活性。从病毒接种前 3 天到接种后 10 天，每天给予 MLT（皮下注射）可减少病毒血症，并显着推迟疾病的发作和死亡 7 至 10 天。此外，注射 MLT 可使接种 SFV (10 PFU) 的小鼠死亡率从 100% 降低至 44%。在接种高剂量 SFV (100 PFU) 的小鼠中，MLT 推迟了死亡并将死亡率降低了 20%。病毒接种后 22 天，所有存活小鼠均检测到抗 SFV 抗体。通过隔离或注射地塞米松 WN-25 应激的小鼠感染分别导致 75% 和 50% 的死亡率，通过 MLT 给药分别将死亡率降低至 31% 和 25%。 MLT 在预防致命病毒感染方面的效率值得进一步研究其作用机制。
We examined the effect of the pineal neurohormone melatonin (MLT) on protection from viral encephalitis. The antiviral activity of MLT was evaluated in normal mice inoculated with Semliki Forest virus (SFV) and in stressed mice injected with the attenuated non-invasive West Nile virus (WN-25). Administration of MLT (s.c.) daily from 3 days before through 10 days after virus inoculation reduced viremia and significantly postponed the onset of disease and death by 7 to 10 days. Moreover, MLT injection reduced mortality of SFV (10 PFU) inoculated mice from 100% to 44%. In mice inoculated with high dose of SFV (100 PFU), MLT postponed death and reduced mortality by 20%. In all of the surviving mice anti-SFV antibodies were detected 22 days after virus inoculation. Infection of mice stressed by either isolation or dexamethasone injection with WN-25 induced mortality of 75% and 50% respectively, which was reduced by MLT administration to 31% and 25%, respectively. The efficiency of MLT in protecting from lethal viral infections warrants further investigations on its mechanisms of action.