Optic disc measurements in myopia with optical coherence tomography and confocal scanning laser ophthalmoscopy
Optic disc measurements in myopia with optical coherence tomography and confocal scanning laser ophthalmoscopy
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DOI：
10.1167/iovs.06-1315
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发表时间：
2007-07-01
影响因子：
4.4
通讯作者：
Lam, Dennis Shun Chiu
中科院分区：
文献类型：
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作者：
Leung, Christopher Kai-shun;Cheng, Arthur Chak Kwan;Lam, Dennis Shun Chiu
目的.目的评价光学相干断层扫描仪和激光共聚焦扫描检眼镜测量视盘参数与近视的关系。分析了133例健康受试者的133只眼，平均等效球镜为-6.0 +/- 4.2 D（范围：-13.13至+3.25 D）。用光学相干断层扫描仪（StratusOCT; Carl Zeiss Meditec Inc.，都柏林，CA）和共焦扫描激光检眼镜（Heidelberg Retina Tomograph，HRT 3; Heidelberg Engineering，GmbH，Dossenheim，德国）。使用来自先前发表的工作的改进的轴长方法来校正用于眼睛放大的OCT测量。使用Bland-Altman图评价每个视盘参数的一致性。通过线性回归分析评价视盘面积与眼轴长度/等效球镜之间的关系。在HRT和校正的OCT测量中，椎间盘面积随着轴长/负等效球镜增加，尽管当OCT测量未校正放大倍数时，发现了相反的相关方向。校正后OCT和HRT椎间盘面积之差（校正后OCT椎间盘面积减去HRT椎间盘面积）与眼轴长度相关（r = 0.195，P = 0.025）。当屈光不正限制在-8.0 ~+4.0D时，HRT的相关性变得不显著。使用校正后的OCT测量值，椎间盘面积、边缘面积和杯面积、杯-盘面积和杯-盘水平和垂直比值均显著大于HRT测量值，其95%一致性范围分别为1.99、1.33和1.86 mm（2），比值分别为0.34、0.53和0.58。结论。虽然视盘面积通常随眼轴长度和近视屈光度的增加而增加，但HRT测量结果表明视盘大小在很大程度上与眼轴长度和-8 ~+4 D的屈光不正无关。OCT可能高估近视眼的视盘大小，导致两种仪器之间的一致性较差。
PURPOSE. To evaluate the relationships between optic disc measurements, obtained by an optical coherence tomograph and a confocal scanning laser ophthalmoscope, and myopia.METHODS. One hundred thirty-three eyes from 133 healthy subjects with mean spherical equivalent -6.0 +/- 4.2 D ( range, -13.13 to + 3.25 D) were analyzed. Optic disc measurements including disc area, rim area, cup area, cup-to-disc area, and vertical and horizontal ratios were obtained with an optical coherence tomograph (StratusOCT; Carl Zeiss Meditec Inc., Dublin, CA) and a confocal scanning laser ophthalmoscope (Heidelberg Retina Tomograph, HRT 3; Heidelberg Engineering, GmbH, Dossenheim, Germany). The modified axial length method derived from prior published work was used to correct the OCT measurements for ocular magnification. Bland-Altman plots were used to evaluate the agreement for each optic disc parameter. Associations between optic disc area and axial length/spherical equivalent were evaluated by linear regression analysis.RESULTS. Disc area increased with the axial length/negative spherical equivalent in the HRT and the corrected OCT measurements although opposite directions of associations were found when the OCT measurements were not corrected for magnification. The difference of the corrected OCT and HRT disc area (corrected OCT disc area minus HRT disc area) was correlated with the axial length (r = 0.195, P = 0.025). When the ametropia was limited to -8.0 to +4.0 D, the correlations became insignificant in the HRT. Using the corrected OCT measurements, disc area, rim area, and cup area, cup-to-disc area, and cup-to-disc horizontal and vertical ratios were significantly larger than those measured by the HRT, with a span of 95% limits of agreement at 1.99, 1.33, and 1.86 mm(2) for the areas, 0.34, 0.53, and 0.58 for the ratios, respectively.CONCLUSIONS. While optic disc area generally increased with the axial length and myopic refraction, the HRT measurements demonstrated that optic disc size was largely independent of axial length and refractive error between -8 and +4 D. OCT may overestimate optic disc size in myopic eyes and results in poor agreement between the two instruments.