Faster ribosome synthesis induced by elevated aortic pressure in rat heart.
Faster ribosome synthesis induced by elevated aortic pressure in rat heart.
复制标题
大鼠心脏主动脉压升高诱导核糖体合成加快。
DOI：
10.1152/ajpcell.1987.252.3.c323
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Morgan,HE
中科院分区：
文献类型：
--
作者：
Chua,BH;Russo,LA;Gordon,EE;Kleinhans,BJ;Morgan,HE
主动脉压从60到120毫米汞柱的增加加速核糖体蛋白质的合成在大鼠心脏在1或2小时的标记与0.4 mM [3H]苯丙氨酸。当心脏灌注缓冲液，含有20 mM的葡萄糖和正常血浆浓度的19种其他氨基酸没有添加胰岛素，核糖体蛋白质合成相对于总蛋白质合成的速率增加约0.22至0.36和0.30主动脉压从60上升到120毫米汞柱在1或2小时的标记，分别。随着胰岛素的加入，核糖体蛋白合成的相对速率在主动脉压为60 mmHg时平均为0.33，当主动脉压升高到120 mmHg时增加到0.42。这些结果表明，主动脉压升高对新核糖体的合成具有优先作用。这种反应似乎是心脏肥大的早期和生理上重要的事件。
An increase in aortic pressure from 60 to 120 mmHg accelerated ribosomal protein synthesis in rat hearts during 1 or 2 h of labeling with 0.4 mM [3H]phenylalanine. When hearts were perfused with buffer that contained 20 mM glucose and normal plasma concentrations of 19 other amino acids without added insulin, ribosomal protein synthesis relative to the rate of total protein synthesis increased from approximately 0.22 to 0.36 and 0.30 as aortic pressure was raised from 60 to 120 mmHg during 1 or 2 h of labeling, respectively. With the addition of insulin, the relative rate of ribosomal protein synthesis averaged 0.33 at an aortic pressure of 60 mmHg and increased to 0.42 when aortic pressure was raised to 120 mmHg. These results indicate that elevation of aortic pressure has a preferential effect on synthesis of new ribosomes. This response appears to be an early and physiologically significant event in cardiac hypertrophy.