Bidirectional Association between Diabetes and Gout: the Singapore Chinese Health Study.
Bidirectional Association between Diabetes and Gout: the Singapore Chinese Health Study.
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DOI：
10.1038/srep25766
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发表时间：
2016-05-10
影响因子：
4.6
通讯作者：
Koh WP
中科院分区：
文献类型：
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作者：
Pan A;Teng GG;Yuan JM;Koh WP
我们的目标是前瞻性地研究2型糖尿病(T2D)和痛风之间的双向关联。我们分析了新加坡华人健康研究的随访数据，在随访I和II中询问了被诊断为糖尿病和痛风的自我报告。参与这两次随访并且在随访I中没有心血管疾病或癌症的个人被包括在内。对于T2D到痛风(分析I)，进一步排除了流行的痛风(最终n = 31,137)。对于痛风到T2D(分析II)，排除了流行的糖尿病(最终n = 28,668)。用COX回归模型估计相对危险度(RR)。在分析I中，糖尿病对682例痛风发病的相对危险度为0.77(95%CI为0.60~0.97)。在分析II中，痛风对糖尿病发病(2223例)的相对危险度为1.36(1.12-1.63)，但在校正高血压和BMI后(1.00；0.83-1.21)变得不显著。痛风与糖尿病的关联被体重指数(P交互作用 = 0.04)和高血压(P交互作用 = 0.007)改变，在患有体重指数24的成年人中略有显著，而在非高血压参与者中显著，但在他们的同龄人中没有。总而言之，我们的结果表明，在正常体重和非高血压成年人中，糖尿病与痛风的发生风险较低，而痛风与糖尿病呈正相关。
We aimed to prospectively investigate the bidirectional association between type 2 diabetes (T2D) and gout. We analyzed follow-up data from the Singapore Chinese Health Study, when self-reports of diagnosed diabetes and gout were enquired at follow-ups I and II. Individuals who participated in both follow-ups and were free of cardiovascular disease or cancer at follow-up I were included. For T2D to gout (analysis I), prevalent gout were further excluded (final n = 31,137). For gout to T2D (analysis II), prevalent diabetes were excluded (final n = 28,668). Cox regression models were used to estimate relative risks (RRs). In the analysis I, the RR of diabetes to incident gout (682 cases) was 0.77 (95% CI 0.60–0.97). In the analysis II, the RR of gout to incident diabetes (2223 cases) was 1.36 (1.12–1.63), but became insignificant after adjustment for hypertension and BMI (1.00; 0.83–1.21). The gout to diabetes association was modified by BMI (Pinteraction = 0.04) and hypertension (Pinteraction = 0.007), and it was marginally significant in adults with BMI<24 while significant among non-hypertensive participants, but not in their counterparts. In conclusion, our results suggest that diabetes is associated with a lower risk of incident gout, while gout is positively related to diabetes among normal weight and non-hypertensive adults.