A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample
A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample
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DOI：
10.1016/j.jad.2010.04.007
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发表时间：
2010-10-01
影响因子：
6.6
通讯作者：
Andreassen, Ole A.
中科院分区：
文献类型：
--
作者：
Djurovic, Srdjan;Gustafsson, Omar;Andreassen, Ole A.
背景资料：在本研究中，我们使用Affyandroid 6.0阵列，在一个同质的挪威样本中调查了与双相情感障碍相关的遗传变异，以及与精神分裂症的潜在遗传重叠。我们在挪威血统的病例对照样本中对620390个单核苷酸多态性（SNPs）进行了基因分型，进行了全基因组关联研究（GWAS（TOP研究）包括双相情感障碍（n = 194）、健康对照（n = 336）和精神分裂症（n = 230），随后在遗传一致的冰岛双相情感障碍样本（n = 435）和健康对照中进行复制和组合分析结果：我们选择了TOP发现GWAS中具有最低P值的1000个标记，并在冰岛复制样本中测试这些（或它们的替代物）的关联。35个基因座的多态性与双相情感障碍相关（名义P值
Background: In the present study we investigated genetic variants associated with bipolar disorder in a homogenous Norwegian sample, and potential genetic overlap with schizophrenia, using the Affymetrix 6.0 array.Methods: We carried out a genome-wide association study (GWAS) by genotyping 620 390 single-nucleotide polymorphisms (SNPs) in a case-control sample of Norwegian origin (the TOP study) including bipolar disorder (n = 194), healthy controls (n = 336) and schizophrenia (n = 230), followed by replication and combined analysis in a genetically concordant Icelandic sample of bipolar disorder (n = 435), and healthy controls (n = 10,258).Results: We selected 1000 markers with the lowest P values in the TOP discovery GWAS and tested these (or their surrogates) for association in the Icelandic replication sample. Polymorphisms on 35 loci were confirmed associated with bipolar disorder (nominal P value