Acute and chronic effects of methotrexate on hepatic, pulmonary, and skeletal systems
Acute and chronic effects of methotrexate on hepatic, pulmonary, and skeletal systems
复制标题
甲氨蝶呤对肝、肺和骨骼系统的急性和慢性影响
作者：
M. Nesbit;W. Krivit;R. Heyn;H. Sharp
随着急性淋巴细胞白血病患儿生存率的逐步提高，治疗对正常组织的远期影响成为一个更重要的问题。在对大量长期接受化疗（尤其是甲氨蝶呤）治疗的儿童的审查中，注意到对肝、肺和骨骼组织的严重影响显著增加。对这些组织中观察到的甲氨蝶呤诱导的急性和慢性变化的审查是本报告的基础。
With the progressive improvement in the survival of children with acute lymphocytic leukemia, the question of late effects of therapy on normal tissue becomes a more significant problem. In a review of a large number of children who have received long‐term treatment with chemotherapy, especially methotrexate, a significant increase in the serious effects on hepatic, pulmonary, and skeletal tissue was noted. A review of the methotrexate‐induced acute and chronic changes seen in these tissues is the basis for this report.