Regulation of expression, activity and localization of fungal chitin synthases.
Regulation of expression, activity and localization of fungal chitin synthases.
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DOI：
10.3109/13693786.2011.577104
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发表时间：
2012-01
期刊：
影响因子：
2.9
通讯作者：
Steinbach WJ
中科院分区：
文献类型：
--
作者：
Rogg LE;Fortwendel JR;Juvvadi PR;Steinbach WJ
真菌细胞壁代表了药理学抑制的有吸引力的靶标，因为许多组分是真菌特异性的。虽然靶向抑制β-葡聚糖合成是某些真菌感染的有效治疗方法，但细胞壁通过细胞壁完整性途径动态补偿的能力可能会限制总体疗效。迄今为止，甲壳素合成抑制剂尚未成功应用于临床。真菌几丁质的合成是一个复杂的、高度调控的过程。几丁质合成的调节发生在多个水平上，因此靶向这些调节途径可能代表一种令人兴奋的替代方法。在转录和转录后水平上，多种信号传导途径都参与了几丁质合成酶的调控。最近的研究表明，本地化的几丁质酶可能是一个主要的调节机制。然而，许多调节机制不一定在不同的几丁质酶之间共享。因此，深入了解每种蛋白质在细胞壁维护和修复中的确切作用对于确定最可能的治疗靶点至关重要。
The fungal cell wall represents an attractive target for pharmacologic inhibition, as many of the components are fungal-specific. Though targeted inhibition of β-glucan synthesis is effective treatment for certain fungal infections, the ability of the cell wall to dynamically compensate via the cell wall integrity pathway may limit overall efficacy. To date, chitin synthesis inhibitors have not been successfully deployed in the clinical setting. Fungal chitin synthesis is a complex and highly regulated process. Regulation of chitin synthesis occurs on multiple levels, thus targeting of these regulatory pathways may represent an exciting alternative approach. A variety of signaling pathways have been implicated in chitin synthase regulation, at both transcriptional and post-transcriptional levels. Recent research suggests that localization of chitin synthases likely represents a major regulatory mechanism. However, much of the regulatory machinery is not necessarily shared among different chitin synthases. Thus, an in depth understanding of the precise roles of each protein in cell wall maintenance and repair will be essential to identifying the most likely therapeutic targets.
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影响因子：
2.9
作者：
Clemons, KV;Stevens, DA
通讯作者：
Stevens, DA
影响因子：
3.6
作者：
AUYOUNG, J;ROBBINS, PW
通讯作者：
ROBBINS, PW
DOI：
10.1006/emyc.1995.1017
发表时间：
1995-06-01
期刊：
EXPERIMENTAL MYCOLOGY
影响因子：
--
作者：
BARTNICKIGARCIA, S;BARTNICKI, DD;BRACKER, CE
通讯作者：
BRACKER, CE
影响因子：
3.3
作者：
Bermejo, Clara;Rodriguez, Estefania;Arroyo, Javier
通讯作者：
Arroyo, Javier
影响因子：
5.3
作者：
CHOI, WJ;SANTOS, B;CABIB, E
通讯作者：
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