Animal models of depression: molecular perspectives.
Animal models of depression: molecular perspectives.
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DOI：
10.1007/7854_2010_108
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发表时间：
2011
影响因子：
--
通讯作者：
Nestler, Eric J
中科院分区：
文献类型：
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作者：
Krishnan, Vaishnav;Nestler, Eric J
目前对抑郁症中情绪改变、注意力不集中和植物神经症状的发病机制的认识大多来自动物模型。然而，由于人类抑郁症的独特和复杂的特征，有效和有见地的抑郁症模型的生成一直不如建模其他致残性疾病，如癌症或自身免疫性疾病。今天流行的抑郁症模型创造性地将行为学上有效的行为分析与分子生物学和自动视频跟踪的最新技术进步相结合。本章回顾了涉及急性应激的抑郁测定（例如，强迫游泳试验），由长时间的身体或社会应激组成的模型（例如，社会失败）、继发性抑郁模型、遗传模型和旨在阐明抗抑郁作用机制的实验。这些范式在其易用性，有效性和可复制性，他们提供的分子见解，以及他们提供下一代抑郁症治疗方法的能力方面进行了严格的评估。
Much of the current understanding about the pathogenesis of altered mood, impaired concentration and neurovegetative symptoms in major depression has come from animal models. However, because of the unique and complex features of human depression, the generation of valid and insightful depression models has been less straightforward than modeling other disabling diseases like cancer or autoimmune conditions. Today’s popular depression models creatively merge ethologically valid behavioral assays with the latest technological advances in molecular biology and automated video-tracking. This chapter reviews depression assays involving acute stress (e.g., forced swim test), models consisting of prolonged physical or social stress (e.g., social defeat), models of secondary depression, genetic models, and experiments designed to elucidate the mechanisms of antidepressant action. These paradigms are critically evaluated in relation to their ease, validity and replicability, the molecular insights that they have provided, and their capacity to offer the next generation of therapeutics for depression.