Secondary polycythemia associated with idiopathic membranous nephropathy
Secondary polycythemia associated with idiopathic membranous nephropathy
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DOI：
10.1159/000013612
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发表时间：
2000-07-01
影响因子：
4.2
通讯作者：
Lee, JS
中科院分区：
文献类型：
--
作者：
Lim, CS;Jung, KH;Lee, JS
一名58岁男性患者继发性红细胞增多症与原发性肾病综合征。肾活检显示膜性肾病，骨髓活检显示骨髓细胞增生伴轻度全增生。血清促红细胞生成素浓度为8.5mU/ml。红细胞增多症的特征是红细胞体积增加（40.2 ml/kg）和动脉血氧饱和度正常。除活检证实的膜性肾病外，无可诱发继发性红细胞增多症的相关病变。He接受泼尼松龙和环磷酰胺治疗，6周后肾病综合征部分缓解。随着肾病综合征的部分缓解，红细胞增多症得到解决。这个病例说明了肾病综合征和红细胞增多症之间的关系，以及红细胞增多症的消退与肾病综合征的改善之间的关系。版权所有（C）2000 S. Karger AG，巴塞尔。
A 58-year-old male patient had secondary polycythemia associated with idiopathic nephrotic syndrome. The renal biopsy revealed membranous nephropathy, and the bone marrow biopsy disclosed hypercellular marrow with mild panhyperplasia. The concentration of serum erythropoietin was 8.5 mU/ml. The erythrocytosis was characterized by an increased red cell volume (40.2 ml/kg) and normal arterial oxygen saturation. There were no associated lesions that could induce secondary polycythemia, except the biopsy-proven membranous nephropathy, He was treated with prednisolone and cyclophosphamide, and the nephrotic syndrome was partially remitted after 6 weeks. With partial remission of nephrotic syndrome, the erythrocytosis was resolved. This case illustrates the rarely reported association of the nephrotic syndrome and erythrocytosis, and the resolution of erythrocytosis with improvement of nephrotic syndrome. Copyright (C) 2000 S. Karger AG, Basel.