Matrix metalloproteinase-1 and skin ageing in smokers
Matrix metalloproteinase-1 and skin ageing in smokers
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DOI：
10.1016/s0140-6736(00)04220-3
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发表时间：
2001-03-24
期刊：
影响因子：
168.9
通讯作者：
Young, AR
中科院分区：
文献类型：
--
作者：
Lahmann, C;Bergemann, J;Young, AR
吸烟者比同龄的不吸烟者看起来更老。我们用实时定量聚合酶链反应比较了吸烟者和非吸烟者臀部皮肤中基质金属蛋白酶1 (MMP-1) mRNA的浓度。MMP-1降解胶原蛋白，胶原蛋白至少占真皮层干重的70%。我们报告吸烟者皮肤中的MMP-1 mRNA明显多于非吸烟者，而金属蛋白酶1的组织抑制剂（TIMP-1）或管家基因GAPDH（甘油醛-3-磷酸脱氢酶）没有差异。我们认为吸烟诱导的MMP-1可能在吸烟的皮肤老化效应中起重要作用。
Smokers look older than non-smokers of the same age. We have compared the concentrations of mRNA for matrix metalloproteinase 1 (MMP-1) in the buttock skin of smokers and non-smokers with quantitative real-time polymerase chain reactions. MMP-1 degrades collagen, which accounts for at least 70% of the dry weight of dermis. We report significantly more MMP-1 mRNA in the skin of smokers than non-smokers whereas no difference was seen for the tissue inhibitor of metalloproteinases 1 (TIMP-1) or the housekeeping gene GAPDH (glyceraldehyde-3-phosphate dehydrogenase). We suggest that smoking-induced MMP-1 might be Important In the skin-ageing effects of tobacco smoking.