Evaluation of a single dose versus a divided dose regimen of danofloxacin in treatment of Actinobacillus pleuropneumoniae infection in pigs
Evaluation of a single dose versus a divided dose regimen of danofloxacin in treatment of Actinobacillus pleuropneumoniae infection in pigs
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DOI：
10.1016/s0034-5288(03)00029-8
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发表时间：
2003-06-01
影响因子：
2.4
通讯作者：
Friis, C
中科院分区：
文献类型：
--
作者：
Lauritzen, B;Lykkesfeldt, J;Friis, C
单次与分次给药方案的达氟沙星治疗猪胸膜肺炎放线杆菌感染进行了评价，使用临床观察结合生化感染标志物：C-反应蛋白，锌和抗坏血酸。实验感染后20小时，18头猪静脉注射单剂量达氟沙星2.5 mg/kg或4剂量0.6 mg/kg，间隔24小时。这些给药方案导致血浆达氟沙星AUC与时间曲线相似。使用单次给药方案的最大浓度高3.5倍，而使用分次给药方案的浓度高于MIC的时间长2.5倍。使用单次给药方案，感染后32小时体温恢复正常。相比之下，正常化延迟至感染后44小时使用四个低剂量和复发与温度升高在52和68小时观察。在临床、血液学或生化观察结果方面，未发现治疗之间的其他显著差异。使用更方便的单次给药方案是适当的，因为它至少与分次给药方案相当。(C)2003爱思唯尔科技有限公司版权所有。
A single versus a divided dose regimen of danofloxacin was evaluated in treatment of porcine Actinobacillus pleuropneumoniae infection using clinical observations combined with biochemical infection markers: C-reactive protein, zinc and ascorbic acid. Twenty hours after experimental infection, the 18 pigs received danofloxacin intravenously as a single dose of 2.5 mg/kg or four doses of 0.6 mg/kg administered at 24 h intervals. These dosage regimens resulted in similar AUCs of the plasma danofloxacin vs time curve. The maximum concentration was 3.5-fold higher using the single dose regimen, while the time with concentrations above the MIC was 2.5-fold longer using the fractionated regimen. Using the single dose regimen, temperature was normalised 32 h post-infection. In contrast, normalisation was delayed until 44 h post-infection using four low doses and a relapse with elevated temperatures at 52 and 68 h was observed. No other significant differences between the treatments were found, neither regarding clinical, haematological nor biochemical observations. The use of the more convenient single dose regimen was appropriate, as it was at least equivalent to the fractionated regimen. (C) 2003 Elsevier Science Ltd. All rights reserved.