Monocular and Binocular Visual Function Deficits in Amblyopic Patients with and without Fusion Maldevelopment Nystagmus.
Monocular and Binocular Visual Function Deficits in Amblyopic Patients with and without Fusion Maldevelopment Nystagmus.
复制标题
伴有或不伴有融合发育不良性眼球震颤的弱视患者的单眼和双眼视觉功能缺陷。
作者：
Murray J;Garg K;Ghasia F
本研究的目的是检查弱视类型和眼球震颤对同伴（FE）和弱视眼（AE）双眼和单眼功能的影响。我们招募了19名对照者和44名弱视者（参差=13，斜视=10，混合型=21）。我们使用阶梯法测量了每只眼睛的视觉、光栅和游标灵敏度以及高/低空间频率（SF）对比灵敏度。立体视敏度用提莫斯蝇试验测定。我们使用高分辨率视频眼动仪记录注视眼动（FEM）。受试者分为无眼震（n=18）、融合性发育不良眼震综合征（FMNS） （n=12）、无任何不符合FMNS或婴儿眼震标准的结构异常眼震（n=14）。视功能的临床弱视类型分析显示，在控制声发射光栅视敏差的情况下，斜视/混合性弱视患者的立体视功能较差（F (2,54)=9.5, p<0.001）。屈光参差患者的FE在低SF （F (2,43)=4.4, p=0.018）和高SF （F (2,42)=10.1, p<0.001）时存在较大的对比敏感度缺陷。通过FEM特征(低SF: （F (3,43)=4.3, p=0.010）和高SF: （F (3,42)=7.1, p=0.001）分析视觉功能，FMNS患者的FE具有较差的低和高SF对比敏感性，而未FMNS患者仅在高SF时与对照组相比有较大的对比敏感性缺陷。FMNS患者（F (3,54) = 12.9, p<0.001）在控制声发射光栅锐度缺陷的情况下，与没有FMNS的患者相比，FMNS患者更容易出现立体视觉不良。所有弱视患者的AE高SF对比敏感性均较差，与类型或FEM特征无关(类型= F (2,43)=8.8, p=0.001；有限元特征= F (3,43)=5.1, p=0.004)。斜视/混合性弱视患者中FMNS的存在与立体视觉不良/缺失有关。弱视类型的FE缺陷各不相同。与FEM异常一样，有眼震或无眼震的患者在FE中也可见视觉功能缺陷。
The aim of the study is to examine the association between amblyopia type and the presence of nystagmus on binocular and monocular functions of the fellow (FE) and amblyopic eye (AE). We recruited 19 controls and 44 amblyopes (anisometropes=13, strabismic=10, mixed=21). We measured visual, grating, and vernier acuities and high/low spatial frequency (SF) contrast sensitivities in each eye using a staircase method. Stereoacuity was measured with the Titmus fly test. We recorded fixation eye movements (FEM) using high-resolution video-oculography. Subjects were classified as having either no nystagmus (n=18), fusion maldevelopment nystagmus syndrome (FMNS) (n=12), or nystagmus without any structural anomalies that does not meet the criteria for FMNS or infantile nystagmus (n=14). Analysis of visual function by clinical amblyopia type showed that patients with strabismus/mixed amblyopia (F (2,54)=9.5, p<0.001) were more likely to have poor stereopsis while controlling for AE grating acuity deficit. The FE of patients with anisometropia had greater contrast sensitivity deficits at low (F (2,43)=4.4, p=0.018) and high SF (F (2,42)=10.1, p<0.001). Analysis of visual function by FEM characteristics (low SF: (F (3,43)=4.3, p=0.010) and high SF: (F (3,42)=7.1, p=0.001) showed that the FE of patients with FMNS had worse low and high SF contrast sensitivities, whereas those without FMNS had greater contrast sensitivity deficits only at high SF compared to controls. Patients with FMNS (F (3,54) = 12.9, p<0.001) were more likely to have poor stereopsis while controlling for AE grating acuity deficit compared to patients without FMNS. All amblyopic patients had worse high SF contrast sensitivity of the AE irrespective of type or FEM characteristics (Type = F (2,43)=8.8, p=0.001; FEM characteristics= F (3,43)=5.1, p=0.004). The presence of FMNS in patients with strabismic/mixed amblyopia is associated with poor/absent stereopsis. FE deficits vary across amblyopia type. Like FEM abnormalities, visual function deficits are seen in the FE of patients with and without nystagmus.