Dissipated energy and efficiency as objective functions for the design of the NeoVAD rotary blood pump.
Dissipated energy and efficiency as objective functions for the design of the NeoVAD rotary blood pump.
复制标题
将耗散能量和效率作为 NeoVAD 旋转式血泵设计的目标函数。
DOI：
10.1109/embc40787.2023.10340919
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Fraser,KatharineH
中科院分区：
文献类型：
--
作者：
Nissim,Lee;Karnik,Shweta;Smith,PAlex;Wang,Yaxin;Fraser,KatharineH
设计旋转血泵时，最大限度地减少溶血性血液损伤是一个重要目标，然而，计算溶血量可能会导致计算成本高昂且不准确。在旋转血泵的设计和分析中，效率和耗散能量是更容易计算的水力参数，尽管有研究表明效率并不是血液相容性的良好指标，即更高效的泵不一定会造成更少的损害，但最近有人推测耗散能量可以作为易于计算的溶血类似物。这项研究表明，出于设计目的，优化最大效率和最小耗散能量在功能上是相同的。有着内在的、密切的联系。此外，使用 NeoVAD 儿科左心室辅助装置完成了旋转式血泵设计的演示，该装置针对两个目标功能进行了优化。由此产生的设计在转子叶片形状上相似，在水力性能上也相似。临床相关性——在给定设计工作点分析旋转式血泵时，这加强了效率和耗散能量之间的直接联系。这引发了以下问题：效率不能用作溶血的易于计算的类比，或者耗散能量以相同方式起作用的有效性。
Minimising haemolytic blood damage is an important objective when designing rotary blood pumps, however, calculating haemolysis can be computationally expensive and inaccurate. Efficiency and dissipated energy are much more easily calculable hydraulic parameters in the design and analysis of rotary blood pumps and although there is work to suggest that efficiency is not a good indicator of haemocompatibility, i.e. more efficient pumps do not necessarily cause less damage, there is recent speculation that dissipated energy can act as an easily calculable haemolysis analogue.This study shows that for design purposes, optimising for maximum efficiency and minimum dissipated energy are functionally the same as they are inherently and closely linked. Moreover a demonstration of rotary blood pump design has been completed using the NeoVAD paediatric left ventricular assist device optimising for both objective functions. The resulting designs appear similar in rotor blade shape and are similar in hydraulic performance.Clinical relevance— This reinforces the direct link between efficiency and dissipated energy when analysing rotary blood pumps at a given design operating point. This raises questions either of the claim that efficiency cannot be used as an easily calculable analogue for haemolysis or the validity of dissipated energy to act in this same manner.