In vivo network models identify sex differences in the spread of tau pathology across the brain.
In vivo network models identify sex differences in the spread of tau pathology across the brain.
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体内网络模型可识别 tau 病理学在大脑中传播的性别差异。
DOI：
10.1002/dad2.12016
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Alzheimer'sDiseaseNeuroimagingInitiative
中科院分区：
文献类型：
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作者：
Shokouhi,Sepideh;Taylor,WarrenD;Albert,Kimberly;Kang,Hakmook;Newhouse,PaulA;Alzheimer'sDiseaseNeuroimagingInitiative
IntroductionWe检查网络的tau连接大脑区域之间的基础上的相关性[18 F]flortaucipir正电子发射断层扫描（PET）的摄取，以评估性别特异性差异在全脑tau propagation.MethodsPET数据的临床正常和轻度认知障碍（MCI）受试者从阿尔茨海默病神经影像学倡议（ADNI）结果基于tau蛋白的网络结构类似于从Braak I期到VI期区域的tau蛋白病的进展。与男性相比，女性具有更高的网络密度和更多的直接区域连接，同时伴有全脑tau蛋白负荷增加，特别是在MCI中。几个区域，包括上级顶叶和海马旁作为社区之间的连接桥梁，在不同的Braak stages.DiscussionNetwork女性的特点可能有利于加速全脑tau蛋白的传播，导致更高的tau蛋白负担的女性比男性MCI的影响更大的女性优势在阿尔茨海默病的诊断。
IntroductionWe examined networks of tau connectivity between brain regions based on correlations of their [18F]flortaucipir positron emission tomography (PET) uptake to evaluate sex‐specific differences in brain‐wide tau propagation.MethodsPET data of clinically normal and mild cognitive impairment (MCI) subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were used to examine differences in network architectures across the groups.ResultsThe tau‐based network architecture resembled progression of tauopathy from Braak stage I to VI regions. Compared to men, women had higher network density and an increased number of direct regional connections in co‐occurrence with increased brain‐wide tau burden, particularly at MCI. Several regions, including superior parietal lobe and parahippocampus served as connecting bridges between communities at different Braak stages.DiscussionNetwork characteristics in women may favor an accelerated brain‐wide tau spread leading to a higher tau burden in women than men with MCI with implications for the greater female preponderance in Alzheimer's disease diagnosis.