Werner's Syndrome: Twenty‐four Cases with a Review of the Japanese Medical Literature
Werner's Syndrome: Twenty‐four Cases with a Review of the Japanese Medical Literature
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沃纳氏综合症：日本医学文献二十四例回顾
DOI：
10.1111/j.1532-5415.1982.tb05617.x
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发表时间：
1982
影响因子：
6.3
通讯作者：
H. Nakashima
中科院分区：
文献类型：
--
作者：
K. Murata;H. Nakashima
对24例Werner综合征病例进行了研究，以确定其临床表现，并与日本医学文献中153例病例的临床综述中发现的临床表现进行比较。24例患者的显著特征为身材矮小、躯干粗壮、四肢纤细、体重较低、鸟状或“蒙面”脸、头发早白或脱落、声音高亢或嘶哑、双侧白内障和各种硬皮病样体征。以前没有强调的三个迹象是反射亢进、扁平足和牙齿发育不规则。描述了7年系列研究期间这些表现的发作和发生率。
Twenty‐four cases of Werner's syndrome were studied to define the clinical manifestations in comparison with those found in a clinical review of 153 cases in the Japanese medical literature. The conspicuous characteristics of the 24 patients were short stature, stocky trunk with thin limbs, low body weight, bird‐like or “masked” face, early graying or loss of hair, high‐pitched or hoarse voice, bilateral cataracts, and various scleroderma‐like signs. Three signs not stressed previously were hyperreflexia, flat feet, and irregular dental development. The onsets and incidences of these manifestations during the seven‐year serial study are described.