Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents
Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents
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DOI：
10.1161/circulationaha.106.657627
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发表时间：
2007-05-15
期刊：
影响因子：
37.8
通讯作者：
Choi, Hyon K.
中科院分区：
文献类型：
--
作者：
Ford, Earl S.;Li, Chaoyang;Choi, Hyon K.
背景-儿童和青少年尿酸浓度与代谢综合征之间的关系仍不完全清楚。本研究的目的是探讨这2个相关的美国儿童和adolescents.Methods和结果的全国代表性样本-我们进行了一个横断面分析，1370名男性和女性年龄在12至17岁，使用数据从全国健康和营养检查调查1999-2002。代谢综合征的患病率在血清尿酸浓度最低四分位数的参与者中< 1%，在第二四分位数中为3.7%，在第三四分位数中为10.3%，在最高四分位数中为21.1%。在校正年龄、性别、人种或种族以及C反应蛋白浓度后，与尿酸最低的2个四分位数（291.5 - 4.9 - 339 μ mol/L）进行比较。从尿酸浓度的最低四分位数开始，血清胰岛素的平均浓度分别为66.2、66.7、79.9和90.9 pmol/L（趋势P < 0.001）。结论：在美国儿童和青少年中，血清尿酸浓度与代谢综合征及其几种组分的患病率密切相关。
Background - The association between concentrations of uric acid and the metabolic syndrome in children and adolescents remains incompletely understood. The objective of this study was to examine how these 2 were associated in a nationally representative sample of US children and adolescents.Methods and Results - We performed a cross-sectional analysis of 1370 males and females aged 12 to 17 years using data from the National Health and Nutrition Examination Survey 1999-2002. The prevalence of the metabolic syndrome was < 1% among participants in the lowest quartile of serum concentration of uric acid, 3.7% in the second quartile, 10.3% in the third quartile, and 21.1% in the highest quartile. Compared with the lowest 2 quartiles of uric acid together ( 291.5 to 4.9 to 339 mu mol/L) after adjustment for age, sex, race or ethnicity, and concentrations of C-reactive protein. Starting with the lowest quartile of concentration of uric acid, mean concentrations of serum insulin were 66.2, 66.7, 79.9, and 90.9 pmol/L for ascending quartiles, respectively (P for trend < 0.001).Conclusions - Among US children and adolescents, serum concentrations of uric acid are strongly associated with the prevalence of the metabolic syndrome and several of its components.