Structural Magnetic Resonance Imaging Demonstrates Abnormal l Regionally-Differential Cortical Thickness Variability in Autism: From Newborns to Adults
Structural Magnetic Resonance Imaging Demonstrates Abnormal l Regionally-Differential Cortical Thickness Variability in Autism: From Newborns to Adults
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DOI：
10.3389/fnhum.2019.00075
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发表时间：
2019-03-14
影响因子：
2.9
通讯作者：
Takahashi, Emi
中科院分区：
文献类型：
--
作者：
Levman, Jacob;MacDonald, Patrick;Takahashi, Emi
自闭症是一组复杂的神经发育障碍，其特征是社会互动受损和限制/重复行为。我们对781名自闭症患者和988名对照受试者（年龄0 - 32岁）的1，996次临床神经结构磁共振成像（MRI）检查进行了大规模回顾性分析，并提取了区域分布的皮质厚度测量值，包括平均测量值以及支持区域内皮质厚度变异性评估的标准差。最年轻的自闭症参与者（<2.5岁）在成像后被诊断出来，并进行了回顾性鉴定。最大的效应量和最常见的发现以前没有在科学文献中发表，涉及影响自闭症大脑许多（但不是所有）区域的皮质厚度的异常区域内变化，这表明自闭症的灰质发育不规则，可以用MRI检测到。非典型发育模式早在0岁时就已在后来被诊断为自闭症的个体中被发现。
Autism is a group of complex neurodevelopmental disorders characterized by impaired social interaction and restricted/repetitive behavior. We performed a large-scale retrospective analysis of 1,996 clinical neurological structural magnetic resonance imaging (MRI) examinations of 781 autistic and 988 control subjects (aged 0-32 years), and extracted regionally distributed cortical thickness measurements, including average measurements as well as standard deviations which supports the assessment of intra-regional cortical thickness variability. The youngest autistic participants (< 2.5 years) were diagnosed after imaging and were identified retrospectively. The largest effect sizes and the most common findings not previously published in the scientific literature involve abnormal intra-regional variability in cortical thickness affecting many (but not all) regions of the autistic brain, suggesting irregular gray matter development in autism that can be detected with MRI. Atypical developmental patterns have been detected as early as 0 years old in individuals who would later be diagnosed with autism.