Examining the language and behavioural profile in FTD and ALS-FTD
Examining the language and behavioural profile in FTD and ALS-FTD
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DOI：
10.1136/jnnp-2017-315667
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发表时间：
2017-08-01
影响因子：
11
通讯作者：
Snowden, Julie S.
中科院分区：
文献类型：
--
作者：
Saxon, Jennifer A.;Thompson, Jennifer C.;Snowden, Julie S.
行为变异性额颞叶痴呆（bvFTD）患者中有一部分会发展为肌萎缩侧索硬化症（ALS）。目前尚不清楚bvFTD合并ALS的行为和认知综合征（ALS- ftd）是否与单独的bvFTD无法区分。方法回顾性分析临床诊断为bvFTD（185例）或ALS-FTD（56例）的241例患者的行为、认知和神经精神症状。根据临床访谈和详细的神经心理学评估记录的信息，将特征分为存在或不存在。结果bvFTD比ALS-FTD更频繁地报告了一些行为和情感变化：社交抑制解除（p . 1）
Background A proportion of patients with behavioural variant frontotemporal dementia (bvFTD) develop amyotrophic lateral sclerosis (ALS). It is currently unknown whether the behavioural and cognitive syndrome in bvFTD with ALS (ALS-FTD) is indistinguishable from that of bvFTD alone.Methods A retrospective cohort of 241 patients with clinical diagnoses of bvFTD (n=185) or ALS-FTD (n=56) was examined with respect to behavioural, cognitive and neuropsychiatric symptoms. Features were rated as present or absent based on information recorded from clinical interviews and detailed neuropsychological assessment.Results A number of behavioural and affective changes were reported more frequently in bvFTD than ALS-FTD: social disinhibition (p