Prognostic factors in children and adolescents with acute myeloid leukemia (excluding children with Down syndrome and acute promyelocytic leukemia): univariate and recursive partitioning analysis of patients treated on Pediatric Oncology Group (POG) Study 8821
Prognostic factors in children and adolescents with acute myeloid leukemia (excluding children with Down syndrome and acute promyelocytic leukemia): univariate and recursive partitioning analysis of patients treated on Pediatric Oncology Group (POG) Study 8821
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儿童和青少年急性髓系白血病（不包括唐氏综合症和急性早幼粒细胞白血病儿童）的预后因素：对接受儿科肿瘤组 (POG) 研究 8821 治疗的患者进行单变量和递归分区分析
作者：
Myron N. Chang;S. Raimondi;Y. Ravindranath;A. Carroll;B. Camitta;M. Gresik;C. Steuber;H. Weinstein
本文的目的是确定与急性髓细胞白血病儿童治疗失败风险相关的临床或生物学特征。从1988年6月至1993年3月，560名儿童和青少年新诊断的急性髓性白血病患者进入儿科肿瘤组研究8821，通过单变量和递归分割方法进行分析。患有唐氏综合征或急性早幼粒细胞白血病的儿童被排除在研究之外。检查的因素包括年龄，白细胞数量，性别，FAB形态亚型，细胞遗传学检查结果和诊断时的髓外疾病。4年时的总体无事件生存率（EFS）为32.7%（s.e.）。= 2.2%）。年龄> 2岁、白细胞低于50 × 109/l、t（8; 21）或inv（16）、染色体正常与EFS发生率较高相关（P值分别为0.003，0.049，0.0003，0.031），而M5亚型AML（P值= 0.0003）和除t（8; 21）和inv（16）以外的染色体异常与较低的EFS发生率相关（P值= 0.0001）。递归划分分析定义了三组预后差异很大的患者：t（8; 21）、inv（16）或正常核型（n = 89）的女性患者预后最好（4年EFS = 55.1%，标准误t（8; 21）、inv（16）或正常染色体的男性患者（n = 106）具有中等预后（4年EFS = 38.1%，s.e. t（8; 21）和inv（16）以外的染色体异常患者（n = 233）预后最差（4年EFS = 27.0%，s.e. = 3.2%）。132例患者（24%）由于细胞遗传学数据缺失而无法分组，主要是由于骨髓样本不足。结果表明，急性髓细胞白血病患儿可分为三个潜在的风险组的预后和性别和染色体异常的差异与EFS的估计差异。这些结果是初步的，必须通过一项大型前瞻性临床试验来证实。
The purpose of the paper was to define clinical or biological features associated with the risk for treatment failure for children with acute myeloid leukemia. Data from 560 children and adolescents with newly diagnosed acute myeloid leukemia who entered the Pediatric Oncology Group Study 8821 from June 1988 to March 1993 were analyzed by univariate and recursive partitioning methods. Children with Down syndrome or acute promyelocytic leukemia were excluded from the study. Factors examined included age, number of leukocytes, sex, FAB morphologic subtype, cytogenetic findings, and extramedullary disease at the time of diagnosis. The overall event-free survival (EFS) rate at 4 years was 32.7% (s.e. = 2.2%). Age ⩾2 years, fewer than 50 × 109/l leukocytes, and t(8;21) or inv(16), and normal chromosomes were associated with higher rates of EFS (P value = 0.003, 0.049, 0.0003, 0.031, respectively), whereas the M5 subtype of AML (P value = 0.0003) and chromosome abnormalities other than t(8;21) and inv(16) were associated with lower rates of EFS (Pvalue = 0.0001). Recursive partitioning analysis defined three groups of patients with widely varied prognoses: female patients with t(8;21), inv(16), or a normal karyotype (n = 89) had the best prognosis (4-year EFS = 55.1%, s.e. = 5.7%); male patients with t(8;21), inv(16) or normal chromosomes (n = 106) had an intermediate prognosis (4-year EFS = 38.1%, s.e. = 5.3%); patients with chromosome abnormalities other than t(8;21) and inv(16) (n = 233) had the worst prognosis (4-year EFS = 27.0%, s.e. = 3.2%). One hundred and thirty-two patients (24%) could not be grouped because of missing cytogenetic data, mainly due to inadequate marrow samples. The results suggest that pediatric patients with acute myeloid leukemia can be categorized into three potential risk groups for prognosis and that differences in sex and chromosomal abnormalities are associated with differences in estimates of EFS. These results are tentative and must be confirmed by a large prospective clinical trial.
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急性髓性白血病的细胞遗传学模式：结果的主要可重复决定因素。
影响因子：
11.4
作者：
Keating,MJ;Smith,TL;Kantarjian,H;Cork,A;Walters,R;Trujillo,JM;McCredie,KB;Gehan,EA;Freireich,EJ
通讯作者：
Freireich,EJ
影响因子：
20.3
作者：
M. Harris;J. Shuster;A. Carroll;A. Look;M. Borowitz;W. Crist;R. Nitschke;J. Pullen;C. Steuber;V. Land
通讯作者：
M. Harris;J. Shuster;A. Carroll;A. Look;M. Borowitz;W. Crist;R. Nitschke;J. Pullen;C. Steuber;V. Land
儿童急性非淋巴细胞白血病诱导治疗和维持治疗的比较：儿科肿瘤小组研究的结果。
DOI：
10.1200/jco.1991.9.2.247
发表时间：
1991
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Steuber,CP;Civin,C;Krischer,J;Culbert,S;Ragab,A;Ruymann,FB;Ravindranath,Y;Leventhal,B;Wilkinson,R;Vietti,TJ
通讯作者：
Vietti,TJ
影响因子：
20.3
作者：
Woods, WG;Kobrinsky, N;Lange, BJ
通讯作者：
Lange, BJ
影响因子：
56.9
作者：
Zhang, JS;Kalkum, M;Roeder, RG
通讯作者：
Roeder, RG