How to Diagnose and Phenotype Asthma
How to Diagnose and Phenotype Asthma
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DOI：
10.1016/j.ccm.2012.05.003
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发表时间：
2012-09-01
影响因子：
5.7
通讯作者：
Chung, Kian Fan
中科院分区：
文献类型：
--
作者：
Nair, Parameswaran;Dasgupta, Angira;Chung, Kian Fan
哮喘被描述为一种以可变气流阻塞、气道高反应性和气道炎症为特征的气道慢性疾病。这篇综述讨论了哮喘的诊断和表型，特别强调了基于细胞炎症和放射成像性质的表型，以及如何利用这些来指导哮喘的治疗，并在未来应用针对特定表型的特异性定向治疗。
Asthma has been described as a chronic disease of the airways characterized by variable airflow obstruction, airway hyperresponsiveness, and airway inflammation. This review discusses the diagnosis and phenotyping of asthma, with a special emphasis on phenotyping based on the nature of cellular inflammation and radiological imaging and how this could be used to direct the treatment of asthma and, in the future, to apply specifically directed therapies to specific phenotypes.