High-density lipoprotein function, dysfunction, and reverse cholesterol transport.
High-density lipoprotein function, dysfunction, and reverse cholesterol transport.
复制标题
高密度脂蛋白功能，功能障碍和反向胆固醇转运。
DOI：
10.1161/atvbaha.112.300133
复制
发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Smith JD
中科院分区：
文献类型：
--
作者：
Fisher EA;Feig JE;Hewing B;Hazen SL;Smith JD
尽管流行病学研究表明高高密度脂蛋白胆固醇水平与降低心血管风险有关，但最近的遗传学和药理学发现对高密度脂蛋白的有益作用提出了质疑。在动物模型中，通过输注或过表达载脂蛋白A-I来提高HDL水平显示出明显的血管改善，如延迟动脉粥样硬化病变进展和加速病变消退，同时增加逆向胆固醇转运。炎症和其他因素，如髓过氧化物酶介导的氧化，可损害HDL的产生和HDL的功能，包括其逆向胆固醇运输、抗氧化和抗炎活性。因此，高密度脂蛋白功能测试虽然尚未发展成为常规诊断方法，但可能证明是有用的，并且比高密度脂蛋白胆固醇水平更能预测心血管风险。
Although high HDL-cholesterol levels are associated with decreased cardiovascular risk in epidemiological studies, recent genetic and pharmacological findings have raised doubts about the beneficial effects of HDL. Raising HDL levels in animal models by infusion or over expression of apolipoprotein A-I has shown clear vascular improvements, such as delayed atherosclerotic lesion progression and accelerated lesion regression, along with increased reverse cholesterol transport. Inflammation and other factors, such as myeloperoxidase mediated oxidation, can impair HDL production and HDL function, in regard to its reverse cholesterol transport, antioxidant, and anti-inflammatory activities. Thus, tests of HDL function, which have not yet been developed as routine diagnostic assays, may prove useful and be a better predictor of cardiovascular risk than HDL-cholesterol levels.