Black Phosphorus Nanosheets as a Neuroprotective Nanomedicine for Neurodegenerative Disorder Therapy
Black Phosphorus Nanosheets as a Neuroprotective Nanomedicine for Neurodegenerative Disorder Therapy
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黑磷纳米片作为神经保护纳米药物用于神经退行性疾病治疗
DOI：
10.1002/adma.201703458
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发表时间：
2018-01-18
影响因子：
29.4
通讯作者：
Guo, Shaojun
中科院分区：
文献类型：
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作者：
Chen, Wansong;Ouyang, Jiang;Guo, Shaojun
过渡金属稳态失调是神经退行性疾病（ND）发生和发展的重要致病因素。过量的过渡金属离子如Cu 2+可以催化细胞毒性活性氧的产生，从而诱导神经细胞凋亡。探索新的螯合剂，不仅能够捕获过量的氧化还原活性金属，而且还可以穿过血脑屏障（BBB），是ND治疗的高度期望。在此，证明了2D黑磷（BP）纳米片可以有效地和选择性地捕获Cu2+以保护神经元细胞免受Cu2+诱导的神经毒性。此外，体外和体内研究均表明，BP纳米片由于具有较强的光热效应，在近红外激光照射下可显著提高血脑屏障通透性，克服了传统螯合剂的缺点。此外，优良的生物相容性和稳定性保证了BP在未来临床应用中的生物安全性。因此，这些特征使得BP纳米片具有作为有效的神经保护纳米药物用于ND治疗的巨大潜力。
Transition-metal dyshomeostasis is recognized as a critical pathogenic factor at the onset and progression of neurodegenerative disorder (ND). Excess transition-metal ions such as Cu2+ can catalyze the generation of cytotoxic reactive oxygen species and thereafter induce neuronal cell apoptosis. Exploring new chelating agents, which are not only capable of capturing excess redox-active metal, but can also cross the blood-brain barrier (BBB), are highly desired for ND therapy. Herein, it is demonstrated that 2D black phosphorus (BP) nanosheets can capture Cu2+ efficiently and selectively to protect neuronal cells from Cu2+-induced neurotoxicity. Moreover, both in vitro and in vivo studies show that the BBB permeability of BP nanosheets is significantly improved under near-infrared laser irradiation due to their strong photothermal effect, which overcomes the drawback of conventional chelating agents. Furthermore, the excellent biocompatibility and stability guarantee the biosafety of BP in future clinical applications. Therefore, these features make BP nanosheets have the great potential to work as an efficient neuroprotective nanodrug for ND therapy.