Baicalein and genistein display differential actions on estrogen receptor (ER) transactivation and apoptosis in MCF-7 cells
Baicalein and genistein display differential actions on estrogen receptor (ER) transactivation and apoptosis in MCF-7 cells
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DOI：
10.1016/s0304-3835(02)00355-5
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发表时间：
2002-12-10
期刊：
影响因子：
9.7
通讯作者：
Leung, LK
中科院分区：
文献类型：
--
作者：
Po, LS;Chen, ZY;Leung, LK
染料木素是一种大豆异黄酮类化合物，因其具有化学预防作用而备受关注。黄芩素是黄芩属植物中发现的一种黄酮类化合物，其结构类似于染料木素。我们利用瞬时转染模型检测了这两种黄酮类化合物的抗雌激素活性。我们的结果表明，黄芩素可以抑制17β雌二醇诱导的雌激素受体α表达细胞的反式激活，而金雀异黄素没有拮抗作用。细胞死亡实验和流式细胞仪分析表明，黄芩素是一种比染料木素更强的细胞凋亡诱导剂。综合所有检测标准，黄芩素可能是一种比染料木素更好的化学预防药物。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
Genistein is a soy isoflavone that has attracted much attention for its chemopreventive properties. Baicalein is a flavone found in Scutellaria species, and its structure is analogous to that of genistein. We examined the two flavones' antiestrogenicity by using a transient transfection model. Our results indicated that baicalein could suppress 17beta-estradiol-induced transactivation in cells expressing estrogen receptor alpha, whereas no antagonistic activity was seen in genistein. Cell death assay and flow cytometry analysis demonstrated that baicalein was a stronger apoptosis inducing agent than genistein. Considering all the criteria tested, baicalein could be a better chemopreventive agent than genistein. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.