Effect of essential amino acid supplementation on muscle and plasma free amino acids in chronic uremia.
Effect of essential amino acid supplementation on muscle and plasma free amino acids in chronic uremia.
复制标题
补充必需氨基酸对慢性尿毒症患者肌肉和血浆游离氨基酸的影响。
作者：
A. Alvestrand;J. Bergström;P. Fürst;G. Germanis;U. Widstam
在慢性尿毒症患者的18克蛋白质饮食2至3周，细胞内的游离氨基酸模式在肌肉是严重异常，低浓度的苏氨酸，缬氨酸，肌肽，和高浓度的天冬氨酸，谷氨酰胺，甘氨酸，丙氨酸和牛磺酸。当蛋白质缺乏的饮食补充必需氨基酸（2至3倍的最低要求）和组氨酸，这些异常得到部分纠正。然而，也观察到其他异常，如细胞内苯丙氨酸和酪氨酸浓度低，赖氨酸、组氨酸、鸟氨酸和瓜氨酸浓度高。
In chronic uremia patients on an 18-g protein diet for 2 to 3 weeks, the intracellular free amino acid pattern in muscle was grossly abnormal, with low concentrations of threonine, valine, carnosine, and high concentrations of aspartate, glutamine, glycine, alanine, and taurine. When the protein-poor diet was supplemented with essential amino acids (2 to 3 times that for minimum requirements) and histidine, these abnormalities were partly corrected. Other abnormalities, however, were observed, such as low intracellular concentrations of phenylalanine and tyrosine, and high concentrations of lysine, histidine, ornithine, and citrulline.