Host-guest complex formation between a water-soluble polyparacyclophane and a hydrophobic guest molecule
Host-guest complex formation between a water-soluble polyparacyclophane and a hydrophobic guest molecule
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水溶性聚对环芳烷和疏水性客体分子之间形成主客体复合物
DOI：
10.1021/ja00527a083
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发表时间：
1980
影响因子：
15
通讯作者：
K. Koga
中科院分区：
文献类型：
--
作者：
K. Odashima;A. Itai;Y. Iitaka;K. Koga
C（21）键。结果形成了一个具有矩形开口端（~ 3.5 X 7.9 Á）21和深度6.5 Á的腔体。客体分子的包合方式如下。正如所预期的，苯环与腔体配合良好，几乎平行于内壁，并且朝向外部的甲基基团部分地从腔体突出。主体和客体分子之间的最紧密接触（< 3.80 Ω）如图1中虚线所示。由于均四甲苯是一种非极性底物，且配合物是在水溶液中形成的，说明疏水相互作用起着重要作用，极性相互作用（即静电相互作用和氢键）不参与均四甲苯与2b-4 HCl之间的配合物形成。基于上述1：1包合物的直接证据，水溶性对环芳通常可用于捕获和固定水溶液中具有确定形状和尺寸的非极性底物。改性的性质的空腔和功能团的引入，现在正在进行中。
C (21) bonds. As a result a cavity is formed which has rectan-gularly shaped open ends (~ 3.5 X 7.9 Á) 21 and a depth of 6.5 Á. The mode of inclusion of the guest molecule is as follows. As expected the benzene ring, fits well with the cavity, being nearly parallel to the inner wall, and the methyl groups which are oriented to the outside protrude partly from the cavity. The closest contacts between the host and guest molecules (< 3.80 Á) are shown in Figure 1 with dotted lines. Since durene is a nonpolar substrate and the complex was obtained from aqueous solution, it is indicated that hydrophobic interaction plays an important role and that polar interactions (ie, electrostatic interaction and hydrogen bonding) do not participate inthe complex formation between 2b-4HCl and durene. On the basis of the direct evidence of 1: 1 inclusion described above, water-soluble paracyclophanes will be generally useful to trap and fix nonpolar substrates of definite shape and size in aqueous solution. Modification of the nature of the cavity and introduction of functional groups are now in progress.