Emulsion templated scaffolds manufactured from photocurable polycaprolactone
Emulsion templated scaffolds manufactured from photocurable polycaprolactone
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DOI：
10.1016/j.polymer.2019.05.023
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发表时间：
2019-06-26
期刊：
影响因子：
4.6
通讯作者：
Claeyssens, Frederik
中科院分区：
文献类型：
--
作者：
Dikici, Betul Aldemir;Sherborne, Colin;Claeyssens, Frederik
乳液模板法是一种制备具有互联孔洞的高孔支架(PolyHIPE)的新兴方法。聚己内酯(PCL)是广泛应用于硬组织和软组织支架材料的合成、生物可吸收聚合物之一。此前已证明，由于聚合物的高粘度限制了乳液两相的有效混合，从PCL配制聚HIPE具有挑战性。本文介绍了通过优化油相稀释剂组成制备光固化四臂聚己内酯甲基丙烯酸酯(4PCLMA)聚合物的研究进展。考察了油相粘度与溶剂组合的关系以及溶剂与油相密度之间的平衡关系。通过使用氯仿作为稀释剂成功地制备了稳定的4PCLMA HIPE和4PCLMA PolyHIPE，通过使用氯仿/甲苯混合物作为稀释剂，我们能够调节孔径。4PCLMA PolyHIPE支架能够支持细胞附着、生长和迁移。
Emulsion templating is an emerging route for the production of highly porous scaffolds (PolyHIPEs) with interconnected porosity. Polycaprolactone (PCL) is one of the most extensively used synthetic, bioresorbable polymer for scaffold materials for both hard and soft tissues. PolyHIPEs have previously been shown to be challenging to formulate from PCL due to the high viscosity of the polymer, which limits the efficient mixing of the two phases of the emulsion. Herein, we present the development of PolyHIPEs made of photocurable 4-arm polycaprolactone methacrylate (4PCLMA) by optimizing the diluting solvent composition of the oil phase. The relationship between oil phase viscosity and solvent combinations, the balance between solvent and oil phase density were investigated. Tuning the balance of these parameters was found to be critical to obtain stable HIPEs.Stable 4PCLMA HIPEs and 4PCLMA PolyHIPEs with open pores were successfully produced via using chloroform as a diluent, and via using chloroform/toluene blends as a diluent, we were able to tune the pore size. 4PCLMA PolyHIPE scaffolds were shown to be capable of supporting cell attachment, growth, and migration.