Change of some oxidative stress parameters after supplementation with whey protein isolate in patients with type 2 diabetes
Change of some oxidative stress parameters after supplementation with whey protein isolate in patients with type 2 diabetes
复制标题
DOI：
10.1016/j.nut.2019.110700
复制
发表时间：
2020-05-01
期刊：
影响因子：
4.4
通讯作者：
Maffioli, Pamela
中科院分区：
文献类型：
--
作者：
Derosa, Giuseppe;D'Angelo, Angela;Maffioli, Pamela
目的：本研究的目的是评价天然半胱氨酸(2.7%)和乳铁蛋白(0.7%)高含量的未变性乳清分离蛋白(WPI；>；=92.5%)对2型糖尿病患者氧化应激和炎症相关参数的影响。方法：将120例糖化血红蛋白=6.5%的2型糖尿病白人患者分为两组。患者每天补充WPI或安慰剂3个月。治疗3个月后，WPI组氧化指标(超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽、还原型谷胱甘肽/氧化型谷胱甘肽比值)和炎症指标(超敏C反应蛋白、白介素6、肿瘤坏死因子-α、丙二醛)均显著低于安慰剂组(P
Objectives: The aim of this study was to evaluate the effects of undenatured whey protein isolate (WPI; >= 92.5%) with a high content of native cysteine (2.7%) and a standardized content of lactoferrin (>= 0.7%) on parameters related to oxidative stress and inflammation in individuals with type 2 diabetes mellitus.Methods: We assigned 120 white patients with type 2 diabetes and glycated hemoglobin >= 6.5% to two groups. The patients were supplemented daily with WPI or placebo for 3 mo. After 3 mo, the markers of oxidation (superoxide dismutase, glutathione peroxidase, glutathione, and reduced glutathione-to-oxidized glutathione ratio) and inflammation (high sensitivity C-reactive protein, interleukin-6, tumor necrosis factor -alpha, malondialdehyde) were significantly lower in the WPI group than in the placebo group (P