Mechanistic insight into sevoflurane-associated developmental neurotoxicity.
Mechanistic insight into sevoflurane-associated developmental neurotoxicity.
复制标题
七氟醚相关发育神经毒性的机制见解
DOI：
10.1007/s10565-021-09677-y
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发表时间：
2022-12
影响因子：
6.1
通讯作者：
中科院分区：
文献类型：
--
作者：
随着技术的发展，越来越多的婴儿在出生后的早期阶段接受全身麻醉进行手术，其他干预或临床检查。然而，全身麻醉药是否会影响发育中的婴儿大脑的功能和结构仍然是一个重要，复杂和有争议的问题。七氟烷是婴儿最常用的麻醉剂，但这种药物具有潜在的神经毒性。短时间或单次暴露于七氟烷对认知功能的影响较弱，而长时间或重复暴露于全身麻醉药可能导致认知功能障碍。本文综述了发育过程中七氟烷暴露可能对大脑产生长期不良影响的机制。我们回顾神经细胞死亡，神经细胞损伤，受损的装配和可塑性的神经回路，tau蛋白磷酸化，神经内分泌效应的重要机制七氟烷诱导的发育神经毒性。应采用更先进的技术和方法来确定七氟烷诱导的神经毒性的潜在机制，并指导预防和治疗。
With the development of technology, more infants receive general anesthesia for surgery, other interventions, or clinical examination at an early stage after birth. However, whether general anesthetics can affect the function and structure of the developing infant brain remains an important, complex, and controversial issue. Sevoflurane is the most-used anesthetic in infants, but this drug is potentially neurotoxic. Short or single exposure to sevoflurane has a weak effect on cognitive function, while long or repeated exposure to general anesthetics may cause cognitive dysfunction. This review focuses on the mechanisms by which sevoflurane exposure during development may induce long-lasting undesirable effects on the brain. We review neural cell death, neural cell damage, impaired assembly and plasticity of neural circuits, tau phosphorylation, and neuroendocrine effects as important mechanisms for sevoflurane-induced developmental neurotoxicity. More advanced technologies and methods should be applied to determine the underlying mechanism(s) and guide prevention and treatment of sevoflurane-induced neurotoxicity.
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DOI：
10.1016/s0140-6736(15)00608-x
发表时间：
2016-01-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Davidson AJ;Disma N;de Graaff JC;Withington DE;Dorris L;Bell G;Stargatt R;Bellinger DC;Schuster T;Arnup SJ;Hardy P;Hunt RW;Takagi MJ;Giribaldi G;Hartmann PL;Salvo I;Morton NS;von Ungern Sternberg BS;Locatelli BG;Wilton N;Lynn A;Thomas JJ;Polaner D;Bagshaw O;Szmuk P;Absalom AR;Frawley G;Berde C;Ormond GD;Marmor J;McCann ME;GAS consortium
通讯作者：
GAS consortium
影响因子：
9.3
作者：
Takahashi K;Funata N;Ikuta F;Sato S
通讯作者：
Sato S
影响因子：
5.7
作者：
DiMaggio C;Sun LS;Li G
通讯作者：
Li G
影响因子：
5
作者：
Chen, Yingle;Li, Shunyuan;Chen, Rulei
通讯作者：
Chen, Rulei
影响因子：
7.6
作者：
Barrett, Ruth M.;Malvaez, Melissa;Wood, Marcelo A.
通讯作者：
Wood, Marcelo A.