Antiproliferative constituents from Umbelliferae plants.: V.: A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica
Antiproliferative constituents from Umbelliferae plants.: V.: A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica
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DOI：
10.1248/cpb.47.96
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发表时间：
1999-01-01
影响因子：
1.7
通讯作者：
Mori, M
中科院分区：
文献类型：
--
作者：
Fujioka, T;Furumi, K;Mori, M
当归CHCl3提取物对人胃腺癌(MK-1)细胞生长有较强的抑制作用。从该提取物中分离得到一个新的呋喃香豆素，命名为日本香豆素和四个呋喃香豆素醚，分别命名为日本香豆素A-D和咖啡酸甲酯，四个多乙酰基化合物(人参醇，法卡地酚，8-O-乙酰基法卡兰二醇，(9Z)-1，9-heptadecadiene-4，6-diyne-3，8，11-triol)，)和八个香豆素(蛇床子素，异欧前胡索素，东五味素，白姜素，花毒素，佛手藤素，氧化前胡黄素和水合前胡黄素)和两个色素类化合物(3‘O-乙酰胡麻酚和水合胡芦巴酚)。根据光谱证据确定了新分离株的结构。报道了分离株对MK-1、HeLa和B16F10细胞株的ED_1。
The CHCl3 extract of the root of Angelica japonica showed high inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. From this extract, a new furanocoumarin named japoangelone and four furanocoumarin ethers of falcarindiol, named japoangelols A-D, were isolated together with caffeic acid methyl eater, four polyacetylenic compounds (panaxynol, falcarindiol, 8-O-acetylfalcarindiol, and (9Z)-1,9-heptadecadiene-4,6-diyne-3,8,11-triol), eight coumarins (osthol, isoimperatorin, scopoletin, byakangelicin, xanthotoxin, bergapten, oxypeucedanin methanolate, and oxypeucedanin hydrate), and two chromones (3'-O-acetylhamaudol, and hamaudol). The structures of the new isolates were determined based on spectral evidence. The ED,, of isolates against MK-1, HeLa, and B16F10 cell lines are reported.