Associations between histogram analysis parameters derived from dynamic-contrast enhanced MRI and PD L1-expression in head and neck squamous cell carcinomas. A preliminary study
Associations between histogram analysis parameters derived from dynamic-contrast enhanced MRI and PD L1-expression in head and neck squamous cell carcinomas. A preliminary study
复制标题
DOI：
10.1016/j.mri.2020.07.005
复制
发表时间：
2020-10-01
影响因子：
2.5
通讯作者：
Surov, Alexey
中科院分区：
文献类型：
--
作者：
Meyer, Hans-Jonas;Hoehn, Anne Kathrin;Surov, Alexey
目的：程序性死亡 1 配体 (PD-L1) 在肿瘤学中发挥着重要作用。通过成像非侵入性地预测其表达可能至关重要。动态对比增强磁共振成像（DCE MRI）是头颈鳞状细胞癌（HNSCC）的重要成像方式之一。本研究的目的是分析 DCE MRI 直方图分析参数与 HNSCC 中 PD-L1 表达之间可能的关联。方法：总体而言，本研究涉及 26 名不同部位的原发性 HNSCC 患者。 DCE MRI 在 3 T MRI 上获得，并使用直方图方法对整个病变测量进行分析。在任何形式的治疗之前，使用 3 个评分（肿瘤阳性评分 (TPS)、免疫细胞评分 (ICS) 和组合阳性评分 (CPS)）估计活检样本上的 PD-L1 表达。结果：CPS 与源自 Ktrans 的模式相关（r = 0.40，p = .04）。 CPS 还与源自 Kep 的 P90 相关（r = 0.40，p = .04）。 ICS 与从 Kep 导出的最大值（r = 0.41，p = .03）和从 Kep 导出的熵（r = 0.43，p = .02）相关。 DCE MRI 参数与 TPS 之间没有关联。结论：源自 DCE MRI 的 Ktrans 和 Kep 相关直方图分析参数与 HNSCC 中免疫细胞的 PD-L1 表达呈中度相关。
Purpose: Programmed death 1 ligand (PD-L1) plays an essential role in oncology. It might be crucial to predict its expression non-invasively by imaging. Dynamic-contrast enhanced MRI (DCE MRI) is one of the important imaging modalities in head and neck squamous cell cancer (HNSCC). The aim of the present study was to analyze possible associations between histogram analysis parameters of DCE MRI and PD-L1 expression in HNSCCMethods: Overall, 26 patients with primary HNSCC of different localizations were involved in the study. DCE MRI was obtained on a 3 T MRI and analyzed with a whole lesion measurement using a histogram approach. PD-L1 expression was estimated on bioptic samples before any form of treatment using 3 scores (Tumor positive score (TPS), Immune cell score (ICS) and Combined positive score (CPS)).Results: CPS correlated with mode derived from Ktrans (r = 0.40, p = .04). Also CPS correlated with P90 derived from Kep (r = 0.40, p = .04). ICS correlated with the maximum derived from Kep (r = 0.41, p = .03) and entropy derived from Kep (r = 0.43, p = .02). There were no associations between DCE MRI parameters and TPS.Conclusion: Ktrans and Kep related histogram analysis parameters derived from DCE MRI correlated moderately with PD-L1 expression of immune cells in HNSCC.