Integrin-α9β1 as a Novel Therapeutic Target for Refractory Diseases: Recent Progress and Insights.
Integrin-α9β1 as a Novel Therapeutic Target for Refractory Diseases: Recent Progress and Insights.
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整合素-α 9 β 1 作为难治性疾病的新治疗靶点：最新进展和见解
DOI：
10.3389/fimmu.2021.638400
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发表时间：
2021
影响因子：
7.3
通讯作者：
Song J
中科院分区：
文献类型：
--
作者：
Xu S;Zhang T;Cao Z;Zhong W;Zhang C;Li H;Song J
整合素是指由α和β亚基组成的异源二聚体。它们作为细胞膜上的受体，与细胞外配体相互作用，介导细胞内分子信号。整合素家族中研究最少的成员之一是整合素-α9β1，它广泛分布于人体各种组织和器官中。整合素-α9β1通过多种复杂的信号通路调节细胞的生理状态，参与一些顽固性疾病的特定病理过程。近年来，越来越多的研究关注α9β1在不同难治性疾病的分子机制中的作用及其作为治疗靶点的潜力。因此，本文对整合素-α9β1的最新研究进行了介绍和总结，阐述了α9β1及其相应配体在癌症、自身免疫性疾病、神经损伤和血栓形成中的协同作用，并强调了α9β1作为治疗这些顽固性疾病的独特靶点的潜力。
Integrins refer to heterodimers consisting of subunits α and β. They serve as receptors on cell membranes and interact with extracellular ligands to mediate intracellular molecular signals. One of the least-studied members of the integrin family is integrin-α9β1, which is widely distributed in various human tissues and organs. Integrin-α9β1 regulates the physiological state of cells through a variety of complex signaling pathways to participate in the specific pathological processes of some intractable diseases. In recent years, an increasing amount of research has focused on the role of α9β1 in the molecular mechanisms of different refractory diseases and its promising potential as a therapeutic target. Accordingly, this review introduces and summarizes recent research related to integrin-α9β1, describes the synergistic functions of α9β1 and its corresponding ligands in cancer, autoimmune diseases, nerve injury and thrombosis and, more importantly, highlights the potential of α9β1 as a distinctive target for the treatment of these intractable diseases.
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影响因子：
4.6
作者：
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Qadri RA
影响因子：
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作者：
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通讯作者：
Butte AJ
影响因子：
15.9
作者：
Bazigou, Eleni;Lyons, Oliver T. A.;Makinen, Taija
通讯作者：
Makinen, Taija
影响因子：
13.5
作者：
Couvelard, A;Bringuier, AF;Scoazec, JY
通讯作者：
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