Hippocampal involvement in retrieval of odor vs. object memories
Hippocampal involvement in retrieval of odor vs. object memories
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DOI：
10.1002/hipo.22073
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发表时间：
2013-02-01
期刊：
影响因子：
3.5
通讯作者：
Haberg, Asta K.
中科院分区：
文献类型：
--
作者：
Lehn, Hanne;Kjonigsen, Lisa J.;Haberg, Asta K.
本研究的目的是调查的作用，人类海马在情节检索的气味，与情节检索的视觉对象。受试者对一组独特的气味和物体进行编码，第二天在功能性磁共振成像（fMRI）中进行检索测试。研究人员向受试者展示了旧的（研究过的）和新的（未研究过的）气味和物体的名称，并要求受试者指出这些刺激中的哪一种是前一天出现的。结果表明，在气味提取过程中，大脑激活比在物体提取过程中更弱，更受限制，这可能反映了一种普遍的视觉优势效应。然而，检索的气味和物体产生重叠的集群激活的双边campi，和左侧激活特别是增加成功检索（命中>正确的拒绝）在这两种方式。此外，气味的检索唯一激活嗅觉皮层区域，可能反映皮层恢复的感觉细节。我们的fMRI研究是第一个直接比较嗅觉和视觉情景记忆的研究，其结果为海马的独立功能提供了明确的证据。(C)2012 Wiley Periodicals，Inc.
The aim of this study was to investigate the role of the human hippocampus in episodic retrieval of odors, in comparison with episodic retrieval of visual objects. Subjects encoded a set of unique odors and objects, and retrieval was tested the next day during functional magnetic resonance imaging (fMRI). Subjects were shown the names of old (studied) and new (unstudied) odors and objects, and asked to indicate which of these stimuli had been presented the previous day. The results showed that brain activation was weaker and more restricted during retrieval of odors than during retrieval of objects, which possibly reflects a general visual dominance effect. Yet, retrieval of odors and objects yielded overlapping clusters of activation the bilateral hippocampi, and the left-sided activation was specifically increased during successful retrieval (hits > correct rejections) in both modalities. Moreover, retrieval of odors uniquely activated olfactory cortical regions, likely to reflect cortical reinstatement of sensory details. Our fMRI study is the first to make a direct comparison between olfactory and visual episodic memory, and the results provide clear evidence for modality-independent functions of the hippocampus. (C) 2012 Wiley Periodicals, Inc.