TIME-DEPENDENT EFFECTS OF CHOLINERGIC BLOCKADE OF THE STRIATUM ON MEMORY
TIME-DEPENDENT EFFECTS OF CHOLINERGIC BLOCKADE OF THE STRIATUM ON MEMORY
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DOI：
10.1016/0304-3940(91)90198-3
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发表时间：
1991-01-14
影响因子：
2.5
通讯作者：
PRADOALCALA, RA
中科院分区：
文献类型：
--
作者：
DELGUANTE, MAD;CRUZMORALES, SE;PRADOALCALA, RA
大鼠接受被动回避任务训练，24小时后进行保留测试。 训练后以不同的时间间隔之一将东莨菪碱注射到前纹状体中：2分钟时产生失忆症；2分钟时产生失忆症；2分钟时产生失忆症。训练后 8 分钟给予时发现中等程度的损伤。 延迟15分钟后，该药物未对记忆产生干扰。 这些观察结果表明纹状体胆碱能活动参与记忆巩固。
Rats were trained on a passive avoidance task, and a retention test was carried out 24 h later. Scopolamine was injected into the anterior striatum at one of various intervals following training: at 2 min it produced amnesia; an intermediate degree of impairment was found when given 8 min after training. With a delay of 15 min, this drug did not produce an interference with memory. These observations suggest that striatal cholinergic activity is involved in memory consolidation.