Neuropsychiatric syndromes in dementia - Results from the European Alzheimer Disease Consortium: Part I
Neuropsychiatric syndromes in dementia - Results from the European Alzheimer Disease Consortium: Part I
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DOI：
10.1159/000110738
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Robert, Philippe H.
中科院分区：
文献类型：
--
作者：
Aalten, Pauline;Verhey, Frans R. J.;Robert, Philippe H.
背景/目的：本研究旨在在大量阿尔茨海默病（AD）门诊患者样本中确定神经精神量表的神经精神亚综合征。方法：收集了来自欧洲阿尔茨海默病联盟12个中心的2354例AD患者的横断面数据。采用主成分分析进行因子分析。结果：结果显示存在4种神经精神亚综合征：多动、精神病性症状、情感症状和淡漠。淡漠亚综合征最为常见，几乎65%的患者存在该症状。结论：这项大型研究为阿尔茨海默病中存在神经精神亚综合征提供了更有力的证据。版权所有（c）2007 S. Karger AG，巴塞尔。
Background/Aims: The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer's disease (AD). Methods: Cross-sectional data of 2,354 patients with AD from 12 centres from the European Alzheimer's Disease Consortium were collected. Principal component analysis was used for factor analysis. Results: The results showed the presence of 4 neuropsychiatric subsyndromes: hyperactivity, psychosis, affective symptoms and apathy. The subsyndrome apathy was the most common, occurring in almost 65% of the patients. Conclusion: This large study has provided additional robust evidence for the existence of neuropsychiatric subsyndromes in AD. Copyright (c) 2007 S. Karger AG, Basel.