Evaluation of Pancreatic Exocrine Secretion Using 13C-Dipeptide (Benzoyl-L-Tyrosyl-[1-13C]Alanine) Breath Test: Focusing on Pancreatoduodenectomy Cases
Evaluation of Pancreatic Exocrine Secretion Using 13C-Dipeptide (Benzoyl-L-Tyrosyl-[1-13C]Alanine) Breath Test: Focusing on Pancreatoduodenectomy Cases
复制标题
使用13C-二肽（苯甲酰-L-酪氨酰-[1-13C]丙氨酸）呼气试验评价胰腺外分泌分泌：以胰十二指肠切除术病例为重点
作者：
Y. Ishii;T. Kohno;A. Ito;Shigeru Suzuki;T. Kohno;T. Takayama;S. Asai
目的：我们研究了使用苯甲酰-L-酪氨酰-[1-13C]丙氨酸(BZ-Tyr-ALA)的呼气试验是否可以评估胰腺外分泌功能。方法：口服苯甲酰-L-酪氨酰-[1-13C]丙氨酸，13CO2的变化以Δ‰表示。本文对慢性胰腺炎患者和健康人进行了呼气试验，并随后对17例胰腺十二指肠切除术患者进行了呼气试验，观察了插管和拔管时呼气试验结果的差异，拔管后呼气试验结果与引流液量的关系，以及慢性胰腺炎有无组织学改变的结果的差异。结果：慢性胰腺炎患者的Δ‰明显低于正常对照组。在术后患者中，插管时的Δ‰高于拔管时。Δ‰与最大胰液容量、平均胰液容量和胰液淀粉酶水平的相关系数分别为0.865、0.757和0.853。11例慢性胰腺炎患者的Δ‰低于6例无组织学改变的慢性胰腺炎患者。结论：BZ-Tyr-Ala呼气试验可以检测胰腺外分泌功能。缩写：BZ-Tyr-Ala-苯甲酰-L-酪氨酸-[1-13C]丙氨酸，BT-PABA-N-苯甲酰-L-酪氨酰-对氨基苯甲酸，ABT-L-[1-13C]丙氨酸呼气试验，慢性胰腺炎，十二指肠乳头癌，胰腺癌-胰头癌
Objectives: We investigated whether a breath test using benzoyl-L-tyrosyl-[1-13C]alanine (Bz-Tyr-Ala) allows assessment of pancreatic exocrine function. Methods: Benzoyl-L-tyrosyl-[1-13C]alanine was orally administered, and changes in 13CO2 were expressed as Δ‰. The breath test was performed in chronic pancreatitis patients and healthy subjects in a preliminary study and, subsequently, in 17 pancreatoduodenectomy patients, to examine the difference between the results obtained at the times of pancreatic tube insertion and removal, the relationship between breath test results after tube removal and the volume of pancreatic juice drained, and the difference in results between the presence versus the absence of histological changes of chronic pancreatitis. Results: The Δ‰ was lower in the chronic pancreatitis patients than in healthy subjects. In the postoperative patients, the Δ‰ was higher at tube insertion than at tube removal. The correlations of the Δ‰ with the maximum volume of pancreatic juice, its mean volume, and pancreatic juice amylase levels were 0.865, 0.757, and 0.853, respectively. The Δ‰ was lower in 11 patients with that in 6 patients without histological changes of chronic pancreatitis. Conclusions: These results suggest that the Bz-Tyr-Ala breath test can measure pancreatic exocrine function.Abbreviations: Bz-Tyr-Ala - benzoyl-L-tyrosyl-[1-13C]alanine, BT-PABA - N-benzoyl-L-tyrosyl-p-aminobenzoic acid, ABT - L-[1-13C]alanine breath test, ChP - chronic pancreatitis, DPC - duodenal papillary carcinoma, PC - pancreatic head cancer
使用 13C 标记的脂质：三辛酸甘油酯、三油酸甘油酯和棕榈酸呼气试验来诊断和鉴别儿童脂肪吸收不良。
影响因子：
29.4
作者：
Watkins,JB;Klein,PD;Schoeller,DA;Kirschner,BS;Park,R;Perman,JA
通讯作者：
Perman,JA