Rapid infant weight gain and advanced skeletal maturation in childhood.
Rapid infant weight gain and advanced skeletal maturation in childhood.
复制标题
婴儿体重快速增加，儿童时期骨骼成熟提前。
DOI：
10.1016/j.jpeds.2009.03.016
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Cameron,Noel
中科院分区：
文献类型：
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作者：
Demerath,EllenW;Jones,LauraL;Hawley,NicolaL;Norris,ShaneA;Pettifor,JohnM;Duren,Dana;Chumlea,WCameron;Towne,Bradford;Cameron,Noel
目的检验美国和南非儿童中婴儿体重快速增加与骨骼发育提前相关的假设。研究设计使用了FELS纵向生长研究(俄亥俄州代顿市)中467名适龄婴儿和出生到20岁队列研究(南非约翰内斯堡)中196名适胎儿的纵向数据。多元线性回归模型检验了体重从0岁到2岁的内部SD评分变化与9岁时的相对骨龄之间的关联，调整了体重指数、身高和其他协变量。结果在这两项研究中，即使调整了9岁时出生体重和身体质量指数的正相关性，婴儿较快的体重增长也与9岁时更早的骨骼成熟(每SD评分约0.2岁或2.4个月)相关(P<；.0001-.005)。这一影响似乎是由于婴儿体重增加较快的受试者童年时身高较高所致。结论相对较快的婴儿体重增加与儿童后期骨骼发育提前有关，可能是通过对身高的影响。
OBJECTIVETo test the hypothesis that rapid infant weight gain is associated with advanced skeletal maturity in children from the United States and South Africa.STUDY DESIGNLongitudinal data from 467 appropriate-for-gestational-age infants in the Fels Longitudinal Growth Study (Dayton, Ohio) and 196 appropriate-for-gestational-age infants in the Birth to Twenty birth cohort study (Johannesburg, South Africa) were used. Multiple linear regression models tested the association between internal SD score change in weight from 0 to 2 years and relative skeletal age at 9 years, adjusting for body mass index, stature, and other covariates.RESULTSIn both studies, faster infant weight gain was associated with more advanced skeletal maturity (approximately 0.2 years or 2.4 months per SD score) at age 9 years (P <.0001-.005), even when adjusting for the positive associations of both birth weight and body mass index at age 9 years. This effect appeared to be accounted for by the greater childhood stature of subjects with more rapid infant weight gain.CONCLUSIONSRelatively rapid infant weight-gain is associated with advanced skeletal development in late childhood, perhaps via effects on stature.