LDL size in African Americans, Hispanics, and non-Hispanic whites -: The insulin resistance atherosclerosis study
LDL size in African Americans, Hispanics, and non-Hispanic whites -: The insulin resistance atherosclerosis study
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DOI：
10.1161/01.atv.19.9.2234
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发表时间：
1999-09-01
影响因子：
8.7
通讯作者：
Mykkänen, L
中科院分区：
文献类型：
--
作者：
Haffner, SM;D'Agostino, R;Mykkänen, L
心血管疾病（CVD）和动脉粥样硬化的患病率在美国的几个少数民族群体中各不相同。最近，小而致密的低密度脂蛋白（LDL）颗粒大小已被认为是CVD的一个危险因素。我们在胰岛素抵抗动脉粥样硬化研究（IRAS）的1571名受试者中研究了LDL大小作为CVD发生率差异的可能解释，IRAS是一项多种族的胰岛素抵抗和心血管危险因素研究。LDL大小（Angstrom）在不同种族之间存在显著差异（非裔美国人262.1+/-0.6，西班牙裔257.6+/-0.6，非西班牙裔白人259.2+/-0.4，P
The prevalence of cardiovascular disease (CVD) and atherosclerosis varies among several minority ethnic groups in the United States. Recently, small, dense low density lipoprotein (LDL) particle size has been recognized as a risk factor for CVD, We examined LDL size as a possible explanation for differences in CVD rates in 1571 subjects from the Insulin Resistance Atherosclerosis Study (IRAS), a multiethnic study of insulin resistance and cardiovascular risk factors. LDL size (Angstrom) was significantly different by ethnic group (African Americans 262.1+/-0.6, Hispanics 257.6+/-0.6, and non-Hispanic whites 259.2+/-0.4, P