Enantioselective effect of flurbiprofen on lithium disposition in rats
Enantioselective effect of flurbiprofen on lithium disposition in rats
复制标题
氟比洛芬对映体选择性对大鼠锂沉积的影响
作者：
Uwai;Y.;Matsumoto;M.;Kawasaki;T.;Nabekura;T.
AimsLithium用于治疗双相情感障碍，主要通过尿液排泄。非甾体抗炎药抑制这一过程。在这项研究中，我们研究了氟比洛芬的对映体选择性作用的处置锂在rats. MethodsPharmacokinetics实验与锂performed.ResultsUntil 60分钟后，静脉注射氯化锂在30 mg/kg作为一个团，17.8%的锂注入回收到尿液中。其肾脏清除率计算为1.62 mL/min/kg。同时注射20 mg/kg的（R）-氟比洛芬对肌酐清除率（Ccr）和锂的药代动力学均无影响。（S）-氟比洛芬损害肾功能，干扰锂的尿排泄。（S）-对映体降低了锂的肾清除率与Ccr的比值。ConclusionThis study clarified that（S）-flurbiprofen but not（R）-flurbiprofen inhibits the renal excretion of lithium in rats.
AimsLithium is administered for treating bipolar disorders and is mainly excreted into urine. Nonsteroidal anti-inflammatory drugs inhibit this process. In this study, we examined the enantioselective effect of flurbiprofen on the disposition of lithium in rats.MethodsPharmacokinetic experiments with lithium were performed.ResultsUntil 60 min after the intravenous administration of lithium chloride at 30 mg/kg as a bolus, 17.8% of lithium injected was recovered into the urine. Its renal clearance was calculated to be 1.62 mL/min/kg. Neither creatinine clearance (C cr) nor pharmacokinetics of lithium was affected by the simultaneous injection of (R)-flurbiprofen at 20 mg/kg.(S)-flurbiprofen impaired the renal function and interfered with the urinary excretion of lithium. The ratio of renal clearance of lithium to C cr was decreased by the (S)-enantiomer.ConclusionThis study clarified that the (S)-flurbiprofen but not (R)-flurbiprofen inhibited the renal excretion of lithium in rats.